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dc.contributor.authorOliveira, Bruna Vasconcelos-
dc.contributor.authorSilva, Paulo Goberlânio de Barros-
dc.contributor.authorNojosa, Jacqueline Santiago-
dc.contributor.authorBrizeno, Luiz André Cavalcante-
dc.contributor.authorFerreira, Jamile Magalhães-
dc.contributor.authorSousa, Fabrício Bitú-
dc.contributor.authorMota, Mário Rogério Lima-
dc.contributor.authorAlves, Ana Paula Negreiros Nunes-
dc.identifier.citationOLIVEIRA, B. V. et al. TNF-alpha expression, evaluation of collagen, and TUNEL of Matricaria recutita L. extract and triamcinolone on oral ulcer in diabetic rats. Journal of Applied Oral Science, Bauru, v. 24, n. 3, p. 278-290, 2016.pt_BR
dc.identifier.issn1678-7765 On line-
dc.description.abstractOBJECTIVES: Characterize the cell profile and immunostaining of proinflammatory markers in an experimental model of bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIALS AND METHODS: Male Wistar rats (n = 6– 7) were treated chronically with saline solution or zoledronic acid (ZA) at 0.04, 0.20, and 1.00 mg kg 1 (1.4 3 10 7, 6.9 3 10 6, and 3.4 3 10 5 mol kg 1), and subsequently, the first left inferior molar was extracted. Were performed counting of viable and empty osteocyte lacunae, viable and apoptotic osteoclasts, polymorphonuclear neutrophil, mast cells (toluidine blue), and the positive presence cells for CD68, tumor necrosis factor-alpha (TNF-a), IL (interleukin)-1b, inducible nitric oxide synthase (iNOS), nuclear factor-kappa B (NF-kB) and IL-18 binding protein (IL-18 bp). RESULTS: BRONJ was showed in ZA treated with 0.20 and 1.00 mg kg 1. There is a dose dependent increase in percentage of empty osteocyte lacunae (P < 0.001) and apoptotic osteoclasts (P < 0.001), counting of total osteoclasts (P = 0.003), polymorphonuclear neutrophil cells (P = 0.009), cytoplasmic-positive cells of CD68 (P < 0.001), TNF-a (P = 0.001), IL-1b (P = 0.001), iNOS (P < 0.001), NF-kB (P = 0.006), and nuclear-positive cells of NF-kB (P = 0.011). Consequently, there is no difference in mast cells (P = 0.957), and IL-18 bp immunostaining decreases dose dependently (P = 0.005). CONCLUSIONS: BRONJ is characterized by increases in immunostaining for proinflammatory markers and NF-kB and inversely associated with cells exhibiting IL-18 bp.pt_BR
dc.publisherJournal of Applied Oral Sciencept_BR
dc.subjectDiabetes Mellituspt_BR
dc.subjectÚlceras Oraispt_BR
dc.titleTNF-alpha expression, evaluation of collagen, and TUNEL of Matricaria recutita L. extract and triamcinolone on oral ulcer in diabetic ratspt_BR
dc.typeArtigo de Periódicopt_BR
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