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Type: Artigo de Periódico
Title: Preclinical evidences for an antimanic effect of carvedilol
Authors: Souza, Greicy Coelho de
Gomes, Julia Ariana de S.
Queiroz, Ana Isabelle de Góis
Araújo, Maíra Morais de
Cavalcante, Lígia Menezes
Machado, Michel de Jesus Souza
Monte, Aline Santos
Lucena, David Freitas de
Quevedo, João
Carvalho, André Ferrer
Macêdo, Danielle
Keywords: Transtorno Bipolar;Bipolar Disorder;Hipertensão
Issue Date: 2015
Publisher: Neural Plasticity
Citation: SOUZA, G. C. de et al. Preclinical evidences for an antimanic effect of carvedilol. Neural Plasticity, v. 2015, p. 1-11, 2015.
Abstract: Oxidative imbalance, alterations in brain-derived neurotrophic factor (BDNF), and mitochondrial dysfunction are implicated in bipolar disorder (BD) pathophysiology and comorbidities, for example, cardiovascular conditions. Carvedilol (CVD), a nonselective beta-blocker widely used for the treatment of hypertension, presents antioxidant and mitochondrial stabilizing properties. Thus, we hypothesized that CVD would prevent and/or reverse mania-like behavioral and neurochemical alterations induced by lisdexamfetamine dimesylate (LDX). To do this, male Wistar rats were submitted to two different protocols, namely, prevention and reversal. In the prevention treatment the rats received daily oral administration (mg/kg) of CVD (2.5, 5 or 7.5), saline, valproate (VAL200), or the combination of CVD5 + VAL100 for 7 days. From the 8th to 14th day LDX was added. In the reversal protocol LDX was administered for 7 days with the drugs being added from the 8th to 14th day of treatment. Two hours after the last administration the behavioral (open field and social interaction) and neurochemical (reduced glutathione, lipid peroxidation, and BDNF) determinations were performed. The results showed that CVD prevented and reversed the behavioral and neurochemical alterations induced by LDX. The administration of CVD5 + VAL100 potentiated the effect of VAL200 alone. Taken together these results demonstrate a possible antimanic effect of CVD in this preclinical model.
ISSN: 1687-5443
Appears in Collections:PPGF - Artigos publicados em revistas científica

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