Please use this identifier to cite or link to this item:
metadata.dc.type: Artigo de Periódico
Title in Portuguese: Neuroprotective properties of the standardized extract from Camellia sinensis (Green Tea) and Its main bioactive components, epicatechin and epigallocatechin gallate, in the 6-OHDA model of Parkinson’s Disease
Author: Pinto, Natália Bitu Pinto,
Alexandre, Bruno da Silva Alexandre
Neves, Kelly Rose Tavares
Silva, Aline Holanda
Leal, Luzia Kalyne Almeida Moreira
Viana, Glauce S. B.
Issue Date: 2015
Publisher: Evidence-Based Complementary and Alternative Medicine
Keywords: Camellia sinensis
Doença de Parkinson
Citation: PINTO, N. B. et al. Neuroprotective properties of the standardized extract from Camellia sinensis (Green Tea) and Its main bioactive components, epicatechin and Epigallocatechin Gallate, in the 6-OHDA model of Parkinson’s disease. Evidence-Based Complementary and Alternative Medicine, v. 2015, p. 1-13, 2015.
Abstract: Camellia sinensis (green tea) is largely consumed, mainly in Asia. It possesses several biological effects such as antioxidant and anti-inflammatory properties. The objectives were to investigate the neuroprotective actions of the standardized extract (CS), epicatechin (EC) and epigallocatechin gallate (EGCG), on a model of Parkinson’s disease. Male Wistar rats were divided into SO (sham-operated controls), untreated 6-OHDA-lesioned and 6-OHDA-lesioned treated for 2 weeks with CS (25, 50, or 100 mg/kg), EC (10 mg/kg), or EGCG (10 mg/kg) groups. One hour after the last administration, animals were submitted to behavioral tests and euthanized and their striata and hippocampi were dissected for neurochemical (DA, DOPAC, and HVA) and antioxidant activity determinations, as well as immunohistochemistry evaluations (TH, COX-2, and iNOS). The results showed that CS and catechins reverted behavioral changes, indicating neuroprotection manifested as decreased rotational behavior, increased locomotor activity, antidepressive effects, and improvement of cognitive dysfunction, as compared to the untreated 6-OHDA-lesioned group. Besides, CS, EP, and EGCG reversed the striatal oxidative stress and immunohistochemistry alterations. These results show that the neuroprotective effects of CS and its catechins are probably and in great part due to its powerful antioxidant and anti-inflammatory properties, pointing out their potential for the prevention and treatment of PD.
ISSN: 1741-427X
Appears in Collections:PPGF - Artigos publicados em revistas científica

Files in This Item:
File Description SizeFormat 
2015_art_nbpinto.pdf3,27 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.