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dc.contributor.authorCorreia, Alyne Oliveira-
dc.contributor.authorCruz, Abílio Augusto Pimentel-
dc.contributor.authorAquino, Arôdo Tenório Ribeiro de-
dc.contributor.authorDiniz, Joanisson Rubens Gomes-
dc.contributor.authorSantana, Karizia Bianca Ferreira-
dc.contributor.authorCidade, Pedro Ivo Martins-
dc.contributor.authorPeixoto, Jaine Dantas-
dc.contributor.authorLucetti, Daniel Luna-
dc.contributor.authorNobre, Maria Elizabeth Pereira-
dc.contributor.authorCruz, Giovany Michely Pinto da-
dc.contributor.authorNeves, Kelly Rose Tavares-
dc.contributor.authorViana, Glauce Socorro de Barros-
dc.identifier.citationCORREIA, A. O. Neuroprotective effects of piperine, an alkaloid from the Piper genus, on the Parkinson's disease model in rats. Journal of Neurology and Therapeutics, v. 1, n. 1, p. 1-8, nov. 2015.pt_BR
dc.description.abstractPiperine (PIP), an alkaloid from the Piper genus plants, presents biological properties, including potent anti-inflammatory actions. Since neuroinflammation plays a key role in Parkinson's disease (PD), the objectives were to evaluate the neuroprotective activity of PIP in a model of PD. Male Wistar rats were divided as: sham-operated (SO), untreated 6-OHDA (lesioned in the right striatum) and 6-OHDA lesioned and treated orally with PIP (5 and 10 mg/kg, 2 weeks). The SO group was injected with saline into the right striatum. The SO and untreated 6-OHDA groups were administered with water, for 2 weeks. All animals were subjected to behavioral (open field, rotarod, and apomorphine-induced rotations tests), neurochemical (DA and DOPAC determinations), histological (fluoro jade staining) and immunohistochemical analyses (TH, DAT, TNF-alpha and iNOS). The results showed that PIP reversed behavioral alterations observed in the untreated 6-OHDA group. DA and DOPAC contents decreased in the striatal lesioned side of the untreated 6-OHDA group, but this change was in part reversed by PIP, at the higher dose. The fluoro jade fluorescence, observed in the untreated 6-OHDA group was attenuated after PIP treatments. Furthermore, increased immunoreactivities for TH and DAT were completely reversed in the lesioned group after PIP treatments. In addition, a partial recovery of increased striatal immunoreactivies for TNF-alpha and iNOS was observed in the lesioned group after PIP treatments. In conclusion, PIP presented a neuroprotective action, probably a consequence of its anti- inflammatory and antioxidant properties, making the drug a potential candidate for the treatment of neurodegenerative diseases as PD.pt_BR
dc.publisherJournal of Neurology and Therapeuticspt_BR
dc.subjectEstresse Oxidativopt_BR
dc.subjectOxidative Stresspt_BR
dc.subjectMal de Parkinsonpt_BR
dc.titleNeuroprotective effects of piperine, an alkaloid from the Piper genus, on the Parkinson's disease model in ratspt_BR
dc.typeArtigo de Periódicopt_BR
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