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dc.contributor.authorAbreu, Paula Araújo de-
dc.contributor.authorWilke, Diego V.-
dc.contributor.authorAraujo, Ana J.-
dc.contributor.authorMarinho-Filho, José Delano B.-
dc.contributor.authorFerreira, Elthon G.-
dc.contributor.authorRibeiro, Carlos Margo R.-
dc.contributor.authorPinheiro, Leandro S.-
dc.contributor.authorAmorim, Juliana W.-
dc.contributor.authorValverde, Alessandra L.-
dc.contributor.authorEpifanio, Rosângela A.-
dc.contributor.authorCosta-Lotufo, Letícia V.-
dc.contributor.authorJimenez, Paula C.-
dc.identifier.citationABREU, P. A. et al. Perezone, from the gorgonian Pseudopterogorgia rigida, induces oxidative stress in human leukemia cells. Revista Brasileira de Farmacognosia, v. 25, n. 6, p. 634-640, nov./dec. 2015.pt_BR
dc.description.abstractFour bisabolanes 1–4, including perezone (1) and triacetyl perezone (2), were isolated through a bioassay-guided fractionation of the extract obtained from the Caribbean gorgonian coral Pseudopterogorgia rigida collected during an expedition cruise to the Bahamas. All isolated compounds showed to be cytotoxic toward panel of four human tumor cell lines, as quantified by the MTT assay after 72 h incubation. Perezone (1), the most active one, was further analyzed, showing to be cytotoxic, but not selective, in a 12-cell line panel comprising tumor and non-tumor, as well as human and murine cells. Additionally, 1 was assayed for cytotoxicity against HL-60 leukemic cells. Pre-treatment with an acute free radical scavenger (l-NAC) before exposure of cells to perezone virtually eliminated the generation of intracellular ROS and lessened its severe cytotoxicity. The protective effect delivered by l-NAC evidences that the mechanism of perezone-induced cytotoxicity is partially associated to production of ROS and a consequent induction of oxidative stress.pt_BR
dc.publisherRevista Brasileira de Farmacognosiapt_BR
dc.subjectEstresse Oxidativopt_BR
dc.subjectOxidative Stresspt_BR
dc.titlePerezone, from the gorgonian pseudopterogorgia rigida, induces oxidative stress in human leukemia cellspt_BR
dc.typeArtigo de Periódicopt_BR
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