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dc.contributor.authorNeves, Kelly Rose Tavares-
dc.contributor.authorNobre Júnior, Hélio Vitoriano-
dc.contributor.authorLeal, Luzia Kalyne Almeida Moreira-
dc.contributor.authorAndrade, Geanne Matos de-
dc.contributor.authorBrito, Gerly Anne de Castro-
dc.contributor.authorViana, Glauce Socorro de Barros-
dc.date.accessioned2016-08-08T14:15:49Z-
dc.date.available2016-08-08T14:15:49Z-
dc.date.issued2015-
dc.identifier.citationNEVES, K. R. T. et al. Pentoxifylline neuroprotective effects are possibly related to Its anti-Inflammatory and TNF-Alpha inhibitory properties, in the 6-OHDA model of Parkinson’s disease. Parkinson's Disease, v. 2015, p. 1-16, 2015.pt_BR
dc.identifier.issn2090-8083-
dc.identifier.issn2042-0080-
dc.identifier.urihttp://www.repositorio.ufc.br/handle/riufc/18971-
dc.description.abstractPentoxifylline (PTX) is a phosphodiesterase inhibitor with anti-TNF-alpha activity, associated with its anti-inflammatory action. Considering Parkinson’s disease (PD) as a neuroinflammatory disorder, the objectives were to evaluate PTX neuroprotective properties, in a model of PD. Male Wistar rats, divided into sham-operated (SO), untreated 6-OHDA, and 6-OHDA treated with PTX (10, 25, and 50 mg/kg) groups, received a unilateral 6-OHDA injection, except the SO group administered with saline. Treatments started 24 h after surgery and continued for 15 days when the animals were submitted to apomorphine-induced rotations, open field, and forced swimming tests. At the next day, they were euthanized and their striata processed for neurochemical (DA and DOPAC determinations), histological, and immunohistochemical (Fluoro-Jade, TH, DAT, OX-42, TNF-alpha, COX-2, and iNOS) studies. PTX reversed the behavioral changes observed in the untreated 6-OHDA animals. Furthermore, PTX partially reversed the decrease in DA contents and improved neuronal viability. In addition, decreases in immunostaining for TH and dopamine transporter (DAT) were reversed. The untreated 6-OHDA group showed intense OX-42, TNF-alpha, COX-2, and iNOS immunoreactivities, which were attenuated by PTX. In conclusion, we demonstrated a neuroprotective effect of PTX, possibly related to its anti-inflammatory and antioxidant actions, indicating its potential as an adjunct treatment for PD.pt_BR
dc.language.isoenpt_BR
dc.publisherParkinson's Diseasept_BR
dc.subjectDoença de Parkinsonpt_BR
dc.subjectPentoxifilinapt_BR
dc.titlePentoxifylline neuroprotective effects are possibly related to its anti-inflammatory and TNF-Alpha inhibitory properties, in the 6-OHDA model of Parkinson’s diseasept_BR
dc.typeArtigo de Periódicopt_BR
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