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Type: Artigo de Periódico
Title: Spirostanol glucosides from the leaves of Cestrum laevigatum L.
Authors: Ribeiro, Paulo Riceli Vasconcelos
Araújo, Ana Jérsia
Costa-Lotufo, Letícia Veras
Braz-Filho, Raimundo
Nobre Júnior, Hélio Vitoriano
Silva, Cecília Rocha da
Andrade Neto, João Batista de
Silveira, Edilberto Rocha
Lima, Mary Anne Sousa
Keywords: Solanaceae;Glicosídeos
Issue Date: Feb-2016
Publisher: Steroids
Citation: RIBEIRO, P. R. V. et al. Spirostanol glucosides from the leaves of Cestrum laevigatum L. Steroids, San Francisco, v. 106, p. 35-40, feb., 2016.
Abstract: Two new steroidal saponins, (25R)-spirost-5-ene-3β,26β-diol 3-O-α-l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-[(1 → 2)-α-l-rhamnopyranosyl]-β-d-glucopyranoside (1) and (25R)-spirost-6-ene-3β,5β-diol 3-O-α-l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-[(1 → 2)-α-l-rhamnopyranosyl]-β-d-glucopyranoside (2), along with the known diosgenin 3-O-α-l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-β-d-glucopyranoside (3), chonglouoside SL-5 (4) and Paris saponin Pb (5) were isolated from the leaves of Cestrum laevigatum. The structures of the compounds were determined using spectroscopic analyses including HRESI-MS, 1D and 2D NMR data, followed by comparison with data from the literature. Among them, two are particularly unique, compound 1 is the first 6Δ-spirostanol saponin and compound 2 has an unusual C-26 hydroxyl in the 5Δ-spirostanol skeleton. Antifungal testing showed a potent activity to formosanin C against Candida albicans and Candida parapsilosis. Evaluation of the cytotoxic activity indicated that compound 1 has a moderate activity against HL-60 and SF-295 cell lines, while compound 2 were active only against HL-60.
ISSN: 0039-128X
Appears in Collections:PPGF - Artigos publicados em revistas científica

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