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metadata.dc.type: Artigo de Periódico
Title in Portuguese: Serum oxidative stress markers and genotoxic profile induced by chemotherapy in patients with breast cancer : a pilot study
Author: Gomes Júnior, Antonio Luiz
Paz, Marcia Fernanda Correia Jardim
Silva, Laís Iasmin Soares da
Carvalho, Simone da Costa e Silva
Sobral, André Luiz Pinho
Machado, Kátia da Conceição
Ferreira, Paulo Michel Pinheiro
Satyal, Prabodh
Freitas, Rivelilson Mendes de
Cavalcante, Ana Amélia de Carvalho
Issue Date: 2015
Publisher: Oxidative Medicine and Cellular Longevity
Keywords: Biomarcadores
Estresse Oxidativo
Citation: GOMES JÚNIOR, A. L. et al. Serum oxidative stress markers and genotoxic profile induced by chemotherapy in patients with breast cancer : a pilot study. Oxidative Medicine and Cellular Longevity, v. 2015, p. 1-12. 2015.
Abstract: The aim of this study was to evaluate the oxidative parameters of erythrocytes and genotoxicity in leukocytes of patients with breastcancer.Oxidativeparametersweredetectedbyspectrophotometryandgenotoxicdamagebysinglecellgelelectrophoresis. Twenty-eight women with breast cancer were monitored before chemotherapy and after the second and fourth cycles of therapy withcyclophosphamideanddoxorubicin.Afterthefourthcycle,increases(𝑃 < 0.05)inthereactivesubstancestothiobarbituric acid levels, nitrite content, and superoxide dismutase activity and high rates of DNA damage in leukocytes were observed when compared with healthy women group and baseline levels. Similarly, after the second cycle, the same parameters were increased (𝑃 < 0.05)whencomparedwithbaselinelevels.Increaseincatalaseactivitywasdetectedonlyafterthefourthcycleandreduced glutathione levels and glutathione peroxidase activity were decreased in all cycles when compared with healthy women, as well as after the second and fourth chemotherapy cycles compared to baseline (𝑃 < 0.05). Patients with breast cancer presented an indicativeofoxidativestressbefore,during,andafterchemotherapy,aswellasincreasedgenotoxicdamageinallstagesoftreatment, demonstratingtheclinicalapplicabilityofthisinvestigation.
ISSN: 1942-0900
Appears in Collections:PPGF - Artigos publicados em revistas científica

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