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Type: Artigo de Periódico
Title: Toxicogenetic profile of rats treated with aqueous extract from Morinda citrifolia fruits
Authors: Moraes, Germano Pinho de
Alencar, Marcus Vinícius Oliveira Barros de
Islam, Torequl
Araújo, Lidiane da Silva
Gomes, Débora Cássia Vieira
Carvalho, Rodrigo Mendes de
Corrêa, Dione
Paz, Márcia Fernanda Correia Jardim
Ferreira, Paulo Michel Pinheiro
Melo-Cavalcante, Ana Amélia de Carvalho
Ferraz, Alexandre
Grivicich, Ivana
Picada, Jaqueline Nascimento
Keywords: Genotoxicidade;Morinda
Issue Date: Feb-2016
Publisher: Journal of Medicinal Plant Research
Citation: MORAES, G. P. de et al. Toxicogenetic profile of rats treated with aqueous extract from Morinda citrifolia fruits. Journal of Medicinal Plant Research, v. 10, n. 2, p. 18-28, feb., 2016.
Abstract: Morinda citrifolia ( (Family: Rubiaceae) ) is extensive ly use d in traditional med icine due to its anti - inflammatory, antimicrobial, antitumoral , and anti - hypertensive act ivities . However, t here is no substantial data about hepatotoxic and toxicogenetic effects . This study evaluated bioch emical changes and hepatotoxic, genotoxic , and mu tagenic effects of aqueous extract of the fruit of M. citrifolia (AEMC) in liver, bone marrow , and peripheral blood cells. A nimals ( Rattus novergicus , 5 males and 5 females) were divided into negative control , positive control ( C yclophosphamid e 25 mg/kg ) , and AEMC (2.5, 5 , and 10 mg/kg , by gavage ) . AEMC induced increase of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), especially at 10 mg/kg in female (174.8 ± 50.7, 221.4 ± 24.6 , and 174.7 ± 14.3 U/L) and m ale ( 156.5 ± 21.6, 183.7 ± 21.5 , and 147.3 ± 17.8 U/L) ( p <0.05). Histological analysis of livers showed inflammatory cell infiltrati on , nuclear fragmentation, microvacuolization, cellular swelling, points of inflammatoy necrosis , and discrete microvesicula r steatosis. DNA damage in hepatocytes w as found in both genders, mainly at 10 mg/kg (Frequency of Damage: 78.1 ± 4.5 and 70.4 ± 7.3%; Index of Damage: 107.6 ± 14.2 and 136.0 ± 26.9 for male and female, respectively). Similar results were observed in bone marrow cells . The AEMC 5 and 10 mg/kg induced micronucleus formation (4.4 ± 0.8 and 7.8 ± 1.1; 7.4 ± 1.1 and 9.6 ± 1.4 for peripheral blood and bone marrow cells, respectively) ( p <0.05). These findings suggest clastogenic and/or aneugenic effects and genet ic instability activated by AEMC , indicating precaution regarding the consumption of formulations or folk preparations based on this plant.
ISSN: 1996 - 0875
Appears in Collections:PPGF - Artigos publicados em revistas científica

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