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Type: Artigo de Periódico
Title: Effects of piperonal nitro derivatives on candida species : antifungal activity against fluconazole - resistant strains is associated with oxidative DNA damage
Authors: Andrade Neto, João Batista de
Silva, Cecília Rocha da
Campos, Rosana de Sousa
Nascimento, Francisca Bruna Stefany Aires do
Freitas, Daniel Domingues
Josino, Maria Aparecida Alexandre
Andrade, Larissa Nara Dantas de
Gonçalves, Thially Braga
Mesquita, Jacó Ricarte Lima de
Magalhães, Hemerson Iury Ferreira
Rodrigues, Felipe Augusto Rocha
Gaspar, Danielle Macedo
Moraes Filho, Manoel Odorico de
Lobo, Marina Duarte Pinto
Moreno, Frederico Bruno Mendes Batista
Grangeiro, Thalles Barbosa
Gomes, Akenaton Onassis Cardoso Viana
Nascente, Luciana de Camargo
Romeiro, Luiz Antonio Soares
Cavalcanti, Bruno Coelho
Nobre Júnior, Hélio Vitoriano
Keywords: Candida;Fluconazol
Issue Date: Apr-2015
Publisher: International Journal of Current Microbiology and Applied Sciences
Citation: ANDRADE NETO, J. B. et al. Effects of piperonal nitro derivatives on candida species : antifungal activity against Fluconazole - resistant strains is associated with oxidative DNA damage. International Journal of Current Microbiology and Applied Sciences, v. 4, n. 4, p. 777-792, abr. 2015.
Abstract: Recently, there has been a significant increase in invasive fungal infections, the treatment of which is limited to a quite small number of antifungal drugs. Natural products represent an important source of antifungal agents, mainly because of their natural coexistence with fungi present in each biome. Derivatives or semi-synthetic products can be used to optimize the pharmacological profile of natural products by modulating relevant biological properties. The present study evaluated the antifungal effect of piperonal nitro derivatives (PNDs) in Candida spp. strains resistant to fluconazole. The assessment of the antifungal effect was determined both by broth dilution and flow cytometry, as well as by the assessment of a potential mechanism of action of these compounds. All of the tested strains were susceptible to the tested compounds. Treatment with PNDs (1, 2 and 3) led to programmed cell death in Candida spp., probably because they play an antifungal role in specific DNA surrounding sites. In addition, ROS production was found to play a role in this process, observed as oxidative damage to DNA purine and pyrimidine bases. The PND compounds (1, 2 and 3) presented antifungal activity in vitro against strains of fluconazoleresistant Candida spp.
ISSN: 2319 - 7706
Appears in Collections:PPGF - Artigos publicados em revistas científica

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