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Type: Artigo de Periódico
Title: Estudo fitoquímico, atividade antimicrobiana e citotóxica de espécimes de Leonotis nepetifolia L. R. (Br)
Title in English: Phytochemical study on antimicrobial and cytotoxic activity of specimens of Leonotis nepetifolia L. R. (Br).
Authors: Oliveira, Ana P.
Guimarães, Amanda L.
Pacheco, Alessandra G. M.
Araújo, Camila S.
Oliveira Júnior, Raimundo G.
Lavor, Érica M.
Silva, Mariana G.
Araújo, Edigênia C. C.
Mendes, Rosemairy L.
Rolim, Larissa A.
Costa, Marcília P.
Farias, Henrique Carvalho Lima
Pessoa, Cláudia do Ó
Lopes, Norberto P.
Marques, Lucas M. M.
Almeida, Jackson Roberto Guedes da Silva
Keywords: Lamiaceae;Plantas Medicinais
Issue Date: Jan-2016
Publisher: Química Nova
Citation: OLIVEIRA, A. P. et al. Estudo fitoquímico, atividade antimicrobiana e citotóxica de espécimes de Leonotis nepetifolia L. R. (Br). Quim. Nova, São Paulo, v. 39, n. 1, p. 32-37, jan., 2016.
Abstract: PHYTOCHEMICAL STUDY ON ANTIMICROBIAL AND CYTOTOXIC ACTIVITY OF SPECIMENS OF Leonotis nepetifolia L. R. (Br). Specimens of Leonotis nepetiflolia were obtained from cultivated and wild environments to verify their influences in chemical composition. Phytochemical analyses were conducted for the ethyl acetate phase obtained by partitioning the crude ethanol extract from the cultivated leaves of L. nepetifolia. In doing so, flavonoid 3’,4’,5-trimethoxy-6,7-dihidroxyflavone (cirsiliol), a chemotaxonomic marker of the family Lamiaceae, was isolated. The results reveal that all phases and extracts tested exhibited weak to moderate antimicrobial activity against the strains of bacteria tested. The evaluation of in vitro cytotoxic and antitumor activity showed that the ethyl acetate phases obtained from both wild and cultivated leaves exhibit high potential cytotoxic and antitumor (> 78.0% of inhibition) activity. The major component of these phases was identified by high-performance liquid chromatography-diode array detector and nuclear magnetic resonance analyses using both 1D and 2D methods. The results further indicate that the flavonoid cirsiliol is the agent responsible for the activity observed in these phases.
ISSN: Impresso 0100-4042
On-line 1678-7064
Appears in Collections:PPGF - Artigos publicados em revistas científica

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