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http://repositorio.ufc.br/handle/riufc/18143| Tipo: | Artigo de Periódico |
| Título: | Effect of propranolol on capsular reaction around silicone implants in guinea pigs |
| Autor(es): | Mesquita, Charles Jean Gomes de Guimarães, Sérgio Botelho Leite Filho, José Alberto Dias Maciel, Felipe Silva Rocha, José Lima de Carvalho Leite, José Alberto Dias |
| Palavras-chave: | Colágeno;Propranolol;Elastômeros de Silicone |
| Data do documento: | Jan-2015 |
| Instituição/Editor/Publicador: | Acta Cirúrgica Brasileira |
| Citação: | MESQUITA, C. J. G. ; GUIMARÃES, S. B. ; LEITE FILHO, J. A. D. ; MACIEL, F. S. ; ROCHA, J. L. C. ; LEITE, J. A. D. (2015) |
| Abstract: | PURPOSE: To evaluate the effect of propranolol on capsular architecture around silicone implants by measuring the inflammation, capsular thickness, and collagen fiber density, using a guinea pig experimental model. METHODS: Thirty six adult male guinea pigs randomly divided into two groups (n=18) were used. Each one received a silicone implant with textured-surface. The capsular tissue around implants from untreated or treated animals with the beta-adrenoceptor antagonist propranolol (10 mg/kg, dissolved in daily water) were analyzed for inflammation by histological scoring, capsular thickness by computerized histometry, and collagen fibers type I and Type III density by picrosirius polarization at different time points (7, 14 or 21 days after silicone implantation). RESULTS: Propranolol treatment reduced inflammation and impaired capsular thickness and delayed collagen maturation around the textured implant. CONCLUSION: Propranolol reduces the risk of developing capsular contracture around silicone implants with textured surface. |
| Descrição: | MESQUITA, Charles Jean Gomes de et al. Effect of propranolol on capsular reaction around silicone implants in guinea pigs. Acta Cirúrgica Brasileira, São Paulo, v. 30, n. 1, p. 24-33, jan. 2015. |
| URI: | http://www.repositorio.ufc.br/handle/riufc/18143 |
| ISSN: | On-line version 1678-2674 |
| Aparece nas coleções: | DCIR - Artigos publicados em revista científica |
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| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| 2015_art_cjgmesquita.pdf | 1,18 MB | Adobe PDF | Visualizar/Abrir |
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