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metadata.dc.type: Artigo de Periódico
Title in Portuguese: Effect of propranolol on capsular reaction around silicone implants in guinea pigs
Author: Mesquita, Charles Jean Gomes de
Guimarães, Sérgio Botelho
Leite Filho, José Alberto Dias
Maciel, Felipe Silva
Rocha, José Lima de Carvalho
Leite, José Alberto Dias
Issue Date: Jan-2015
Publisher: Acta Cirúrgica Brasileira
Keywords: Colágeno
Elastômeros de Silicone
Citation: MESQUITA, C. J. G. ; GUIMARÃES, S. B. ; LEITE FILHO, J. A. D. ; MACIEL, F. S. ; ROCHA, J. L. C. ; LEITE, J. A. D. (2015)
Abstract: PURPOSE: To evaluate the effect of propranolol on capsular architecture around silicone implants by measuring the inflammation, capsular thickness, and collagen fiber density, using a guinea pig experimental model. METHODS: Thirty six adult male guinea pigs randomly divided into two groups (n=18) were used. Each one received a silicone implant with textured-surface. The capsular tissue around implants from untreated or treated animals with the beta-adrenoceptor antagonist propranolol (10 mg/kg, dissolved in daily water) were analyzed for inflammation by histological scoring, capsular thickness by computerized histometry, and collagen fibers type I and Type III density by picrosirius polarization at different time points (7, 14 or 21 days after silicone implantation). RESULTS: Propranolol treatment reduced inflammation and impaired capsular thickness and delayed collagen maturation around the textured implant. CONCLUSION: Propranolol reduces the risk of developing capsular contracture around silicone implants with textured surface.
Description: MESQUITA, Charles Jean Gomes de et al. Effect of propranolol on capsular reaction around silicone implants in guinea pigs. Acta Cirúrgica Brasileira, São Paulo, v. 30, n. 1, p. 24-33, jan. 2015.
ISSN: On-line version 1678-2674
Appears in Collections:DCIR - Artigos publicados em revista científica

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