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metadata.dc.type: Artigo de Periódico
Title in Portuguese: Development of a subcutaneous endometriosis rat model
Author: Pereira, Francisco Edson Ximenes Gomes
Almeida, Paulo Roberto Carvalho de
Dias, Bruno Hállan Meneses
Vasconcelos, Paulo Roberto Leitão de
Guimarães, Sérgio Botelho Guimarães
Medeiros, Francisco das Chagas
Issue Date: Jan-2015
Publisher: Acta Cirúrgica Brasileira
Keywords: Endometriose
Pamoato de Triptorrelina
Citation: PEREIRA, F. E. X. G. et al. Development of a subcutaneous endometriosis rat model. Acta Cirúrgica Brasileira, São Paulo, v. 30, n. 1, p. 1-7, jan. 2015.
Abstract: PURPOSE: To present a rat model of subcutaneous endometriosis for the study of pathophysiology and the effects of drugs. METHODS: Fifty three-month-old female Wistar rats (Rattus norvergicus) were distributed into one control group and four treatment groups: estradiol (2.5; 5; 10mg/kg sc), medroxyprogesterone acetate (0.5; 2; 5mg/kg sc), triptorelin pamoate (0.18; 0.56mg/kg sc) and acetylsalicylic acid (3mg/kg per os). The animals were autoimplanted subcutaneously with 4x4-mm uterine fragments to induce endometriosis. The endometriomas were measured on days 1, 7, 14 and 21. The relative dry and wet weights of the endometrioma were used to evaluate response to the drug. Endometrial -like tissue was confirmed by histology. The greatest weight gain was observed on day 14 (relative wet weight: 29.1 ± 6.7mg%, relative dry weight: 5.3 ± 0.9mg %). Treatments were administered between day 5 and day 14. RESULTS: The relative wet weight of the hemiuterus in the 10mg/kg estradiol group differed significantly from control and the other two estradiol groups (p=0.0001). In the medroxyprogesterone acetate group the weight decreased significantly but this decrease was not dose-dependent. Weight reduction was also significant in the triptorelin pamoate and the acetylsalicylic acid groups. CONCLUSION: The model of subcutaneous endometriosis is reproducible, low-cost and easy to perform, and suitable for the study of pathophysiology and the effects of drugs.
ISSN: On-line version 1678-2674
Appears in Collections:DCIR - Artigos publicados em revista científica

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