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Type: Artigo de Periódico
Title: Preconditioning with mono and polyunsaturated fatty acids and low-intensity electrical stimulation. Effects on skin repair in rats
Authors: Cardoso, Maria dos Prazeres Carneiro
Albuquerque, Andréa de Oliveira
Girão, Virgínia Cláudia Carneiro
Pompeu, Margarida Maria de Lima
Silva, Cícero Igor Simões Moura
Azevedo, Orleâncio Gomes Ripardo de
Guimarães, Sergio Botelho
Vasconcelos, Paulo Roberto Leitão de
Keywords: Óleos;Cicatrização;Pele
Issue Date: Feb-2015
Publisher: Acta Cirúrgica Brasileira
Citation: CARDOSO, M. dos P. C. et al. Preconditioning with mono and polyunsaturated fatty acids and low-intensity electrical stimulation. Effects on skin repair in rats. Acta Cirúrgica Brasileira, São Paulo, v. 30, n. 2, p. 107-114, feb. 2015.
Abstract: PURPOSE: To evaluate the effects of preconditioning with oils mixes containing ω3/ω6/ω9 associated with micro-currents on skin repair in rats. METHODS: One-hundred and eight Wistar rats randomized into G-1, G-2 and G-3 groups were treated with saline (0.9%), mix 1 (corn+soybean oils) and mix 2 (olive+canola+flaxseed oils), respectively, in a single dose (0.01ml/g) by gavage. Next, each group was subdivided into sham and stimulated subgroups. Pulsed-wave microcurrents (0.5 µA, 0.5 Hz) were applied to stimulated subgroups for 20 min. One hour later anesthetized rats were subjected to surgery. A dorsal incision (6 cm long) was carried out and closed with interrupted nylon sutures. Samples (1cm2) were harvested from the mid-portion of the incision on the 7, 14, 21 post-operative (P.O.) days. Variables were analyzed using Mann-Whitney/Dunn tests Significance level was set to 5 % (p<0.05). RESULTS: Micro-currents promoted increase of exudate and reduction of epithelialization on day 7 in G1 rats. Mixes 1/2 reduced vascularization on 7/14th days P.O. Both 1/2 mixes reduced fibrosis on day 14. Preconditioning with mix 1 led to increased expression of NF-kB on the 7th day. CONCLUSION: Preconditioning with microcurrents has pro-inflammatory effects while oil mixes 1 and 2 decrease fibrosis and vascularization in the proliferative phase of cicatrization.
ISSN: 1678-2674 On-line
Appears in Collections:PPGF - Artigos publicados em revistas científica

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