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metadata.dc.type: Artigo de Periódico
Title in Portuguese: Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms
Author: Nunes, Rodolfo de Melo
Martins, Morgana Ramos
Silva Junior, Francisco Saraiva da
Leite, Ana Caroline Rocha de Melo
Girão, Virgínia Cláudia Carneiro
Cunha, Fernando de Queiroz
Marinho, Aryana Lushese Lima Feitosa
Pinto, Ana Carolina Matias Dinelly
Rocha, Francisco Airton Castro
Issue Date: Oct-2015
Publisher: Inflammation Research
Keywords: Artrite
Citation: NUNES, R. M. et al. Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms. Inflammation Research, Basel, v. 64, n. 10, p. 781-787, oct. 2015.
Abstract: Objective We investigated the anti-inflammatory activity of strontium ranelate (SR) in arthritis models. Materials and methods Rats received 1 mg zymosan (Zy) or saline intra-articularly. Other groups were subjected to anterior cruciate ligament transection in the right knee, as an osteoarthritis (OA) model, or a sham procedure. Joint pain was assessed using the articular incapacitation and paw-pressure tests. Cell influx and cytokines were measured in joint exudates. Treatment Groups received either SR (30–300 mg/kg per os) or saline. Results SR dose-dependently and significantly inhibited joint pain in both Zy and OA models, while not altering cell influx. Naloxone administration significantly reversed SR analgesia. SR significantly reduced levels of Interleukin-1β and tumor necrosis factor-α in Zy arthritis, whereas those of cytokine-induced neutrophil chemoattractant (CINC)-1 were not altered. Conclusions SR provides analgesia in arthritis that is associated to inhibition of the release of inflammatory cytokines into inflamed joints. This effect is abrogated by administration of the opioid antagonist naloxone.
ISSN: 1023-3830
Appears in Collections:DMC - Artigos publicados em revistas científicas

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