Please use this identifier to cite or link to this item:
Title in Portuguese: The resin from protium heptaphyllum prevents high-fat diet-induced obesity in mice : scientific evidence and potential mechanisms
Author: Carvalho, Karine Maria Martins Bezerra
MarinhoFilho, José Delano Barreto
Melo, Tiago Sousa de
Araújo, Ana Jérsia
Quetz, Josiane da Silva
Cunha, Mariado Perpétuo Socorro Saldanha da
Melo, Karina Moura de
Silva, Armenio Andrede Carvalho Almeida da
Tomé, Adriana Rocha
Havt, Alexandre
Fonseca, Said Gonçalves da Cruz
Brito, Gerly Annede Castro
Chaves, Mariana Helena
Rao, Vietla Satyanarayana
Santos, Flávia Almeida
Keywords: Dieta
Issue Date: Jan-2015
Publisher: Evidence-Based Complementary and Alternative Medicine
Citation: CARVALHO, K. M. M. B. et al. The resin from protium heptaphyllum prevents high-fat diet-induced obesity in mice : scientific evidence and potential mechanisms. Evidence-Based Complementary and Alternative Medicine, v. 2015, p. 1-13, jan. 2015.
Abstract: Herbal compounds rich in triterpenes are well known to regulate glucose and lipid metabolism and to have beneficial effects on metabolicdisorders.ThepresentstudyinvestigatedtheantiobesitypropertiesofresinfromProtiumheptaphyllum(RPH)andthe possible mechanisms in mice fed a high-fat diet (HFD) for 15 weeks. Mice treated with RPH showed decreases in body weight, netenergyintake,abdominalfataccumulation,plasmaglucose,amylase,lipase,triglycerides,andtotalcholesterolrelativetotheir respectivecontrols,whichwereRPHunfed.Additionally,RPHtreatment,whilesignificantlyelevatingtheplasmalevelofghrelin hormone,decreasedthelevelsofinsulin,leptin,andresistin.Besides,HFD-inducedincreasesinplasmalevelsofproinflammatory mediators TNF-𝛼, IL-6, and MCP-1 were significantly lowered by RPH. Furthermore, in vitro studies revealed that RPH could significantly inhibit the lipid accumulation in 3T3-L1 adipocytes (measured by Oil-Red O staining) at concentrations up to 50𝜇g/mL.ThesefindingssuggestthattheantiobesepotentialofRPHislargelyduetoitsmodulatoryeffectsonvarioushormonal andenzymaticsecretionsrelatedtofatandcarbohydratemetabolismandtotheregulationofobesity-associatedinflammation.
metadata.dc.type: Artigo de Periódico
ISSN: 1741-427X
Appears in Collections:DMC - Artigos publicados em revistas científicas

Files in This Item:
File Description SizeFormat 
2015_art_kmmbcarvalho.pdf2,3 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.