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Type: Artigo de Periódico
Title: Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state
Authors: Moreira, Juliane Almeida
Laurentino, Marília Rocha
Machado, Rosângela Pinheiro Gonçalves
Barbosa, Maritza Cavalcante
Gonçalves, Ronaldo Pinheiro
Mota, Amanda de Menezes
Rocha, Lilianne Brito da Silva
Martins, Alice Maria Costa
Arruda, Alcínia Braga de Lima
Souza, Iêda Pereira de
Gonçalves, Romélia Pinheiro
Keywords: Anemia;Hemoglobina
Issue Date: 2015
Publisher: Revista Brasileira de Hematologia e Hemoterapia
Citation: MOREIRA, J. A. et al. Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 37, n. 3, p. 167-171, maio/jun. 2015.
Abstract: Objective: This study aimed to evaluate the influence of fetal hemoglobin (Hb F) on hemolysis biomarkers in sickle cell anemia patients. Methods: Fifty adult sickle cell anemia patients were included in the study. All patients were taking hydroxyurea for at least six months and were followed at the outpatient clinic of a hospital in Fortaleza, Ceará, Brazil. The control group consisted of 20 hemoglobin AA individuals. The reticulocyte count was performed by an automated methodology, lac- tate dehydrogenase and uric acid were measured by spectrophotometry and arginase I by enzyme-linked immunosorbent assay (ELISA). The presence of Hb S was detected by high-performance liquid chromatography. The level of significance was set for a p -value <0.05. Results: A significant increase was observed in the reticulocyte count and lactate dehy- drogenase, uric acid and arginase I levels in sickle cell anemia patients compared to the control group ( p -value <0.05). Patients having Hb F levels greater than 10% showed a signifi- cant decrease in the reticulocyte count, arginase I and lactate dehydrogenase. A significant decrease was observed in arginase I levels in patients taking hydroxyurea at a dose greater than 20 mg/kg/day. Conclusion: The results of this study show that sickle cell anemia patients have increases in the hemolysis biomarkers, lactate dehydrogenase, reticulocyte count, arginase I, uric acid and increases in Hb F can reduce the reticulocyte count and arginase I and lactate dehydrogenase levels.
ISSN: 1516-8484
Appears in Collections:DPML - Artigos publicados em revista científica

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