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Title in Portuguese: Antifungal resistance and virulence among Candida spp. from captive amazonian manatees and west Indian manatees : potential impacts on animal and environmental health
Author: Sidrim, José Júlio Costa
Carvalho, Vitor Luz
Castelo-Branco, Débora de Souza Collares Maia
Brilhante, Raimunda Sâmia Nogueira
Guedes, Gláucia Morgana de Melo
Barbosa, Giovanna Riello
Lazzarini, Stella Maris
Oliveira, Daniella Carvalho Ribeiro
Meirelles, Ana Carolina Oliveira de
Attademo, Fernanda Löffler Niemeyer
Freire, Augusto Carlos da Bôaviagem
Pereira-Neto, Pereira-Neto
Cordeiro, Rossana de Aguiar
Moreira, José Luciano Bezerra
Rocha, Marcos Fábio Gadelha
Keywords: Trichechus
Saúde Ambiental
Issue Date: Jan-2016
Publisher: Ecohealth
Citation: SIDRIM, J. J. C. et al. Antifungal resistance and virulence among Candida spp. from captive Amazonian manatees and west Indian manatees : potential impacts on animal and environmental health. Ecohealth, New York, p. 1-11, jan. 2016.
Abstract: This work aimed at evaluating the antifungal susceptibility and production of virulence factors by Candida spp. isolated from sirenians in Brazil. The isolates (n = 105) were recovered from the natural cavities of Amazonian and West Indian manatees and were tested for the susceptibility to amphotericin B, itraconazole, and fluconazole and for the production of phospholipases, proteases, and biofilm. The minimum inhibitory concentrations (MICs) for amphotericin B ranged from 0.03 to 1 lg/mL, and no resistant isolates were detected. Itraconazole and fluconazole MICs ranged from 0.03 to 16 lg/mL and from 0.125 to 64 lg/mL, respectively, and 35.2% (37/105) of the isolates were resistant to at least one of these azole drugs. Concerning the production of virulence factors, phospholipase activity was observed in 67.6% (71/105) of the isolates, while protease activity and biofilm production were detected in 50.5% (53/105) and 32.4% (34/105) of the isolates, respectively. Since the natural cavities of manatees are colonized by resistant and virulent strains of Candida spp., these animals can act as sources of resistance and virulence genes for the environment, conspecifics and other animal species, demonstrating the potential environmental impacts associated with their release back into their natural habitat.
metadata.dc.type: Artigo de Periódico
Appears in Collections:DPML - Artigos publicados em revista científica

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