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Title in Portuguese: Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice : evidence for involvement of the monoaminergic system
Author: Citó, M. C. O.
Silva, Maria Izabel Gomes
Santos, Luciana Kelly Ximenes
Fernandes, M. L.
Melo, Francisca Helvira Cavalcante
Aguiar, Joaquim Abilio Cisne
Lopes, Iardja Stéfane
Sousa, P .B.
Vasconcelos, Silvânia Maria Mendes de
Macêdo, D. S.
Sousa, Francisca Cléa Florenço de
Keywords: Depressão
Issue Date: Jan-2015
Publisher: Brazilian journal of medical and biological research
Citation: CITÓ, M.C.O. et al. Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice : evidence for involvement of the monoaminergic system. Braz J Med Biol Res, Ribeirão Preto, v. 48, n. 1, p. 57-64, jan. 2015.
Abstract: Hoodia gordonii is a plant species used traditionally in southern Africa to suppress appetite. Recently, it has been associated with a significant increase in blood pressure and pulse rate in women, suggesting sympathomimetic activity. The present study investigated the possible antidepressant-like effects of acute and repeated (15 days) administration of H. gordonii extract (25 and 50 mg/kg, po) to mice exposed to a forced swimming test (FST). Neurochemical analysis of brain monoamines was also carried out to determine the involvement of the monoaminergic system on these effects. Acute administration of H. gordonii decreased the immobility of mice in the FST without accompanying changes in general activity in the open-field test during acute treatment, suggesting an antidepressant-like effect. The anti-immobility effect of H. gordonii was prevented by pretreatment of mice with PCPA [an inhibitor of serotonin (5-HT) synthesis], NAN-190 (a 5-HT1A antagonist), ritanserin (a 5-HT2A/2C antagonist), ondansetron (a 5-HT3A antagonist), prazosin (an a1-adrenoceptor antagonist), SCH23390 (a D1 receptor antagonist), yohimbine (an a2-adrenoceptor antagonist), and sulpiride (a D2 receptor antagonist). A significant increase in 5-HT levels in the striatum was detected after acute administration, while 5-HT, norepinephrine and dopamine were significantly elevated after chronic treatment. Results indicated that H. gordonii possesses antidepressant-like activity in the FST by altering the dopaminergic, serotonergic, and noradrenergic systems.
metadata.dc.type: Artigo de Periódico
ISSN: 1414-431X
Appears in Collections:DFIFA - Artigos publicados em revista científica

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