http://repositorio.ufc.br/handle/riufc/41717 Sat, 11 Apr 2026 11:08:52 GMT 2026-04-11T11:08:52Z http://repositorio.ufc.br/handle/riufc/82680 Título: Antinociceptive Effect of the Monoterpene R-()-Limonene in Mice Autor(es): Amaral, Jeferson Falcão do; Silva, Maria Izabel Gomes; Neto, Manuel Rufino de Aquino; Neto, Paulo Florentino Teixeira; Moura, Brinell Arcanjo; Melo, Carla Thiciane Vasconcelos de; Araújo, Fernando Luiz Oliveira de; Sousa, Damião Pergentino de; Vasconcelos, Patrícia Freire de; Vasconcelos, Silvânia Maria Mendes de; Sousa, Francisca Cléa Florenço de Abstract: In the present study were studied the antinociceptives properties of monoterpene R-()-limonene (LM) in chemical and thermal models of nociception in mice. The R-()-limonene was administered, intraperitoneally(i.p.), at doses of 25 and 50 mg/kg. The results showed significant inhibition produced on chemical nociception induced by intraperitoneal acetic-acid and in the second phase of subplantar formalin test, but did not manifest a significant effect in hot-plate test. The R-()-limonene-induced antinociception in second phase of formalin test was insensitive to naloxone (1 mg/kg, s.c.). It was also demonstrated that R-()-limonene (25, 50 mg/kg) neither significantly enhanced the pentobarbital-sleeping time nor impaired the motor performance in rota-rod test, indicating that the observed antinociception is unlikely to be due to sedation or motor abnormality. In conclusion it may be suggested that the R-()-limonene presented antinociceptive activity and that, probably, this action can be related with peripheral analgesia, but, not with the stimulation of opioids receptors. Tipo: Artigo de Periódico Mon, 01 Jan 2007 00:00:00 GMT http://repositorio.ufc.br/handle/riufc/82680 2007-01-01T00:00:00Z http://repositorio.ufc.br/handle/riufc/82678 Título: Polimorfismo do gene do receptor de progesterona (PROGINS) em mulheres com câncer de mama. Estudo caso-controle Autor(es): Linhares, José Juvenal; Silva, Ismael Dale Cotrim Guerreiro da; Souza, Naiara Correa Nogueira de; Noronha, Emmanuelle Coelho; Ferraro, Odair; Baracat, Fausto Farah Abstract: to analyze the correlation between PROGINS polymorphism and breast cancer. Methods: a case-control study was carried out from April to October 2004. The genotypes of 50 women with breast cancer and 49 healthy women were analyzed. The 306-base pair Alu insertion polymorphism in the G intron of progesterone receptor gene was detected by polymerase chain reaction and analyzed on 2% agarose gel stained with ethidium bromide. The control and experimental groups were compared regarding genotypes using the statistical Epi-Info 6.0 program and for frequencies the exact Fisher test or χ2 test were used. p value smaller p than 5% was considered to be significant. Results: in relation to PROGINS we found in the studied population a prevalence of 62 (62.6%) wild homozygous, 35 (35.3%) heterozygous individuals and two (2.1%) cases with the presence of the mutation. Regarding PROGINS polymorphism, significance was not evidenced when cases and controls were compared, as related to homozygosis (62 vs 65.3%), heterozygosis (36 vs 34,6%) or the mutation (2.0 vs 2.1%), with p=0.920 (OR=1.01), 0.891 (OR=1.06), and 0.988 (OR=1.10), respectively. Conclusions: the results show that single-gene PROGINS polymorphism does not confer a substantial risk of breast cancer to its carriers. Tipo: Artigo de Periódico Sat, 01 Jan 2005 00:00:00 GMT http://repositorio.ufc.br/handle/riufc/82678 2005-01-01T00:00:00Z http://repositorio.ufc.br/handle/riufc/80679 Título: Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies Autor(es): Linhares, José Juvenal; Silva, Ismael Dale Cotrim Guerreiro da; Souza, Naiara C. Nogueira de; Noronha, Emmanuelle Coelho; Ferraro, Odair; Carvalho, Cristina Valleta de; Baracat, Edmund Chada; Baracat, Fausto Farah Abstract: Due to the conflicting results regarding the association between breast cancer and the GSTM1 null mutation, our aim was to research this association in a Brazilian population and correlations with smoking, reproductive history and several clinical pathologies. A case-control study was performed on 105 women with breast cancer and 278 controls. Extraction of DNA was accomplished according to the protocol of the GFX® kit and polymorphism analysis by the PCR technique. The control and experimental groups were compared and statistical analysis assessed by X2 or Fisher’s exact test. The deletion in the GSTM1 gene in the breast cancer group had a prevalence of 32 (30.4%) individuals with the presence of null mutation. In the control group, the null mutation was present in 104 (37.4%) women. Upon comparison of the two groups, no statistically significant difference of the GSTM1 gene was observed, with an odds ratio (OR) of 0.74, 95%, confidence interval (CI) 0.45 - 1.20, p = 0.277. The results conclusively show that single gene GSTM1 polymorphisms do not confer a substantial risk of breast cancer to its carriers. Furthermore, in this study no correlation was found between GSTs and smoking, reproductive history and several clinical pathologies with respect to cancer risk. Tipo: Artigo de Periódico Sat, 01 Jan 2005 00:00:00 GMT http://repositorio.ufc.br/handle/riufc/80679 2005-01-01T00:00:00Z http://repositorio.ufc.br/handle/riufc/80006 Título: Uso de células de linhagem TIGEF para cultivo e produção de lentivírus ovino Autor(es): Virgínio, Camila Gomes; Teixeira, Maria Fátima da Silva Abstract: This article presents a review of cell culture concerning diagnostic virology and its use for ovine lentivirus diagnosis, through the improvement caused due to the introduction of a cell line named TIGEF, considered an advance for better study of the biological and molecular characteristics of ovine lentivirus infection. Tipo: Artigo de Periódico Thu, 01 Jan 2004 00:00:00 GMT http://repositorio.ufc.br/handle/riufc/80006 2004-01-01T00:00:00Z