DSpace Coleção:
http://repositorio.ufc.br/handle/riufc/46775
2024-03-19T01:34:30ZAtividade antibacteriana e moduladora do óleo essencial de Allium sativum L. (Alho)
http://repositorio.ufc.br/handle/riufc/63034
Título: Atividade antibacteriana e moduladora do óleo essencial de Allium sativum L. (Alho)
Autor(es): Silva, Álife Diêgo Lima; Monteiro, Maria de Fátima Guedes; Sousa Júnior, Dárcio Luiz de; Macêdo, Nair Silva Macêdo; Saraiva, Cícero Roberto Nascimento; Leandro, Maria Karollyna do Nascimento Silva; Aquino, Pedro Everson Alexandre de; Silva, Rakel Olinda Macedo da; Leandro, Lívia Maria Garcia
Abstract: The present study aims to evaluate the antibacterial and modulating activity of the essential oil of Allium sativum L. (OEAs) associated with LED lights. The essential oil was obtained by hydrodistillation and the antibacterial and modulating activity was performed by the gas contact method with the use of yellow, blue and red LED light along with the antibiotics amikacin, ciprofloxacin, gentamicin, norfloxacin, oxacycline and penicillin. The tests were performed in triplicate and submitted to ANOVA statistical analysis with significance test for p <0.05. In the direct antibacterial activity there was no inhibition of the growth of the tested strains and for the OAS + antibiotic + LED lights (modulation of antibacterial resistance) combinations with multi-resistant strains of Escherichia coli 27 and Staphylococcus aureus 358 there was a possible synergism with the antibiotics amikacin, ciprofloxacin, norfloxacin and oxacillin. These results become important in collaboration with future research for new ways of treating diseases caused by multi-resistant bacteria.
Tipo: Artigo de Periódico2019-01-01T00:00:00ZCaracterização fitoquímica e atividade antibacteriana do extrato etanólico e do óleo essencial das folhas de Cymbopogon citratus phytochemical
http://repositorio.ufc.br/handle/riufc/63030
Título: Caracterização fitoquímica e atividade antibacteriana do extrato etanólico e do óleo essencial das folhas de Cymbopogon citratus phytochemical
Autor(es): Santos, Damires Inácio dos; Sousa Júnior, Dárcio Luiz de; Monteiro, Maria de Fátima Guedes; Aquino, Pedro Everson Alexandre de; Saraiva, Cícero Roberto Nascimento; Leandro, Maria Karollyna do Nascimento Silva; Silva, Rakel Olinda Macedo da; Leandro, Lívia Maria Garcia
Abstract: Cymbopogon citratus is a well known and used vegetable, belonging to the Paeceae family, originated in Asia and in some tropical countries, popularly known as Capim-santo is effective against various pathologies such as asthma, insomnia, colic and anxiety. The present study aimed to determine the phytochemical profile of the ethanolic extract and essential oil from C. citratus leaves, as well as the antibacterial and modulatory activity against standard and multidrug-resistant Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa bacteria. For the analysis of antibacterial activity, the broth microdilution test was performed to determine the minimum inhibitory concentration (MIC), and the modulatory activity of the aminoglycosides gentamicin and amikacin. In the phytochemical characterization it was observed the presence of phenolic compounds in the extract as tannins and phenols, besides presenting some flavonoids. The obtained results of the MIC in all tested bacteria was ≥1024 μg/mL for both the extract and the essential oil. The ethanolic extract, when associated with amikacin and gentamicin, showed antagonism to S. aureus and P. aeruginosa strains, but when the essential oil and antibiotics were combined, there was antagonism only to P. aeruginosa, the other results were not significant. Thus, new studies with other antibiotics should be carried out, aiming to seek the effects caused by this type of combined activity, because, as in the data obtained, the reduction of the antibiotic effect can hinder the treatment of various diseases.
Tipo: Artigo de Periódico2021-01-01T00:00:00ZRapid and long-lasting antidepressant-like effects of ketamine and their relationship with the expression of brain enzymes, BDNF, and astrocytes
http://repositorio.ufc.br/handle/riufc/63028
Título: Rapid and long-lasting antidepressant-like effects of ketamine and their relationship with the expression of brain enzymes, BDNF, and astrocytes
Autor(es): Viana, Glauce S. B.; Vale, Eduardo Mulato do; Araujo, A. R. A. de; Coelho, N. C.; Andrade, S. M.; Costa, R. O. da; Aquino, Pedro Everson Alexandre de; Sousa, C. N. S. de; Medeiros, I. S. de; Vasconcelos, Silvânia Maria Mendes de; Neves, Kelly Rose Tavares
Abstract: Ketamine (KET) is an N-methyl-D-aspartate (NMDA) antagonist with rapid and long-lasting antidepressant effects, but how the
drug shows its sustained effects is still a matter of controversy. The objectives were to evaluate the mechanisms for KET rapid
(30 min) and long-lasting (15 and 30 days after) antidepressant effects in mice. A single dose of KET (2, 5, or 10 mg/kg, po) was
administered to male Swiss mice and the forced swim test (FST) was performed 30 min, 15, or 30 days later. Imipramine (IMI,
30 mg/kg, ip), a tricyclic antidepressant drug, was used as reference. The mice were euthanized, separated into two time-point
groups (D1, first day after KET injection; D30, 30 days later), and brain sections were processed for glycogen synthase kinase-3
(GSK-3), histone deacetylase (HDAC), brain-derived neurotrophic factor (BDNF), and glial fibrillary acidic protein (GFAP)
immunohistochemical assays. KET (5 and 10 mg/kg) presented rapid and long-lasting antidepressant-like effects. As expected,
the immunoreactivities for brain GSK-3 and HDAC decreased compared to control groups in all areas (striatum, DG, CA1, CA3,
and mainly pre-frontal cortex, PFC) after KET injection. Increases in BDNF immunostaining were demonstrated in the PFC, DG,
CA1, and CA3 areas at D1 and D30 time-points. GFAP immunoreactivity was also increased in the PFC and striatum at both
time-points. In conclusion, KET changed brain BDNF and GFAP expressions 30 days after a single administration. Although
neuroplasticity could be involved in the observed effects of KET, more studies are needed to explain the mechanisms for the
drug’s sustained antidepressant-like effects.
Tipo: Artigo de Periódico2021-01-01T00:00:00ZKinase inhibition in relapsed/refractory leukemia and lymphoma settings: recent prospects into clinical investigations
http://repositorio.ufc.br/handle/riufc/62960
Título: Kinase inhibition in relapsed/refractory leukemia and lymphoma settings: recent prospects into clinical investigations
Autor(es): Machado, Caio Bezerra; Pessoa, Flávia Melo Cunha de Pinho; Silva, Emerson Lucena da; Pantoja, Laudreísa da Costa; Ribeiro, Rodrigo Monteiro; Moraes Filho, Manoel Odorico de; Moraes, Maria Elisabete Amaral de; Montenegro, Raquel Carvalho; Burbano, Rommel Mário Rodriguez; Khayat, André Salim; Moreira-Nunes, Caroline Aquino
Abstract: Cancer is still a major barrier to life expectancy increase worldwide, and hematologic
neoplasms represent a relevant percentage of cancer incidence rates. Tumor dependence of continuous
proliferative signals mediated through protein kinases overexpression instigated increased
strategies of kinase inhibition in the oncologic practice over the last couple decades, and in this review,
we focused our discussion on relevant clinical trials of the past five years that investigated kinase
inhibitor (KI) usage in patients afflicted with relapsed/refractory (R/R) hematologic malignancies as
well as in the pharmacological characteristics of available KIs and the dissertation about traditional
chemotherapy treatment approaches and its hindrances. A trend towards investigations on KI usage
for the treatment of chronic lymphoid leukemia and acute myeloid leukemia in R/R settings was
observed, and it likely reflects the existence of already established treatment protocols for chronic
myeloid leukemia and acute lymphoid leukemia patient cohorts. Overall, regimens of KI treatment
are clinically manageable, and results are especially effective when allied with tumor genetic profiles,
giving rise to encouraging future prospects of an era where chemotherapy-free treatment regimens
are a reality for many oncologic patients.
Tipo: Artigo de Periódico2021-01-01T00:00:00Z