DSpace Communidade:http://repositorio.ufc.br/handle/riufc/582026-06-12T05:31:39Z2026-06-12T05:31:39ZEstudo racional de triterpenos do tipo lanostano como potenciais inibidores da proteína MYC: avaliação in silicoOliveira, José Augusto Carneiro dehttp://repositorio.ufc.br/handle/riufc/867112026-06-11T12:46:31Z2026-01-01T00:00:00ZTítulo: Estudo racional de triterpenos do tipo lanostano como potenciais inibidores da proteína MYC: avaliação in silico
Autor(es): Oliveira, José Augusto Carneiro de
Abstract: The MYC protein is one of the most investigated molecular targets for anticancer therapy. The structural characteristics of this intrinsically disordered protein have made inhibitor development a challenge. Lanostane-type triterpenes, such as pisosterol, are secondary metabolites constantly investigated for their anticancer activities. In this study, the anti-MYC potential of 821 lanostane-type triterpenes was investigated using ensemble docking, structural property prediction, pharmacokinetic parameters, molecular dynamics, and free energy calculation using the MM-GBSA method. As a result, the ligands (I-VIII) known as ganoderic acid E (I), ganoderlactone D (II), ganoderic acid Y (III), ganoderic acid Df (IV), lucidenic acid F (V), ganoderic acid XL4 (VI), mariessiic acid A (VII), and phellinol E (VIII) exhibited properties within the filters used. These eight ligands interacted with the molecular target, presenting interaction energies between -8.3 and -8.6 kcal.mol-1. In molecular dynamics, the RMSD, RMSF, radius of gyration, and hydrogen bonding plots revealed that ligands I, IV, VI, and VII interacted satisfactorily with the protein during the simulations, contributing to its conformational and energetic stabilization. The MYC-I and MYC-VII complexes presented free energies of -41.96 kcal.mol-1 and -44.98 kcal.mol-1, respectively. These results demonstrate that lanostane-type triterpenes were able to interact with MYC, forming stable complexes, suggesting that these molecules have the potential to inhibit the target
Tipo: Tese2026-01-01T00:00:00ZPotencial dendrocronológico e relações clima-crescimento em espécies de manguezalSilva, Mateus de Oliveirahttp://repositorio.ufc.br/handle/riufc/866112026-06-10T12:31:03Z2026-01-01T00:00:00ZTítulo: Potencial dendrocronológico e relações clima-crescimento em espécies de manguezal
Autor(es): Silva, Mateus de Oliveira
Tipo: Dissertação2026-01-01T00:00:00ZUma abordagem estruturada para observabilidade em microsserviços: taxonomia, catálogo e framework de detecção de anti-padrõesGomes, Francisco Anderson de Almadahttp://repositorio.ufc.br/handle/riufc/865822026-06-02T22:52:56Z2026-01-01T00:00:00ZTítulo: Uma abordagem estruturada para observabilidade em microsserviços: taxonomia, catálogo e framework de detecção de anti-padrões
Autor(es): Gomes, Francisco Anderson de Almada
Abstract: Software systems increasingly rely on microservices-based architectures to enhance scalability, modularity, and continuous deployment. Although this approach simplifies development by promoting a functional decomposition of components, it also introduces significant operational complexity, making failures more frequent and harder to diagnose. In this context, observability emerges as a fundamental concept, defined as the ability to understand and diagnose the internal behavior of a system based on its external outputs, such as metrics, logs, and traces. However, despite its importance, observability is often poorly implemented due to the lack of standardized practices, resulting in ineffective monitoring, alert fatigue, and low efficiency in incident response. Although existing studies discuss concepts, tools, and challenges related to observability, no prior work has focused specifically on observability anti-patterns, recurrent practices that undermine monitoring effectiveness, nor proposed solutions capable of detecting them automatically. Furthermore, there is a lack of a comprehensive taxonomy to classify and organize existing studies on observability. To address these gaps, this thesis presents a taxonomy focused on observability in microservices-based applications, constructed through a systematic mapping of the literature. A total of 84 relevant studies published between 2019 and 2025 were analyzed, providing a comprehensive overview of the field. The review also identifies tools, benchmarking applications, and real-world datasets used in the selected studies. Complementing this contribution, the thesis develops a systematized catalog of observability anti-patterns, offering an approach to identify and mitigate harmful practices. This catalog serves as a practical guide to support teams in building more reliable and efficient systems. In total, 37 anti-patterns were identified, whose relevance was evaluated by 60 experts, achieving an agreement rate of 95%. Finally, the thesis introduces the Observa framework, designed to automatically detect observability anti-patterns. Its operation was evaluated through three experiments and a proof of concept, which demonstrated its technical feasibility and approved its adoption, receiving a recommendation of excellence from the evaluators.
Tipo: Tese2026-01-01T00:00:00ZAcaparamiento verde y transicion energetica justa: analisis de casos en LatinoamericaSuarez, Andrea Fabianahttp://repositorio.ufc.br/handle/riufc/865732026-06-02T14:47:38Z2025-01-01T00:00:00ZTítulo: Acaparamiento verde y transicion energetica justa: analisis de casos en Latinoamerica
Autor(es): Suarez, Andrea Fabiana
Tipo: Dissertação2025-01-01T00:00:00Z