http://repositorio.ufc.br/handle/riufc/400 2026-05-18T11:39:40Z 2026-05-18T11:39:40Z Cavalcante, Francisco Roger Aguiar Cavalcante, Kellyn Kessiene de Sousa Florencio, Caroline Mary Gurgel Dias Moreno, Jarier de Oliveira Correia, Francisco Gustavo Silveira Alencar, Carlos Henrique http://repositorio.ufc.br/handle/riufc/51354 2020-04-20T14:23:51Z 2020-02-01T00:00:00Z

Título: Human visceral leishmaniasis: epidemiological, temporal and spacial aspects in Northeast Brazil, 2003-2017 Autor(es): Cavalcante, Francisco Roger Aguiar; Cavalcante, Kellyn Kessiene de Sousa; Florencio, Caroline Mary Gurgel Dias; Moreno, Jarier de Oliveira; Correia, Francisco Gustavo Silveira; Alencar, Carlos Henrique Abstract: Visceral leishmaniasis is a highly lethal zoonosis transmitted by a sandfly. It is caused by a Leishmania protozoan parasite and dogs are the main reservoir. Ceara State is endemic to visceral leishmaniasis and it is considered a high risk transmission area. Temporal and spatial epidemiological studies have been used as tools to analyze the distribution and frequency of human visceral leishmaniasis (HVL). This study aimed to characterize HVL in its epidemiological andtemporal aspects in Ceara State, from 2003 to 2017, as this is a neglected disease and a public health problem. This is an ecological study carried out with HVL confirmed cases in Ceara, using three blocks of years (2003 to 2007, 2008 to 2012 and 2013 to 2017). The disease presented an endemic behavior, affecting mainly male residents in the urban area, especially children under five and young adults between 30 and 49 years old. HVL is recorded in all the municipalities, for more than 10 years, with a growing trend and territorial expansion to the Central and Eastern regions of the State. The results of this study indicated the increase in the incidence and lethality, as well as the expansion of leishmaniasis in Ceara State. Tipo: Artigo de Periódico

2020-02-01T00:00:00Z Cordeiro, Rossana de Aguiar Evangelista, Antonio Jose de Jesus Serpa, Rosana Andrade, Ana Raquel Colares de Mendes, Patrícia Bruna Leite Oliveira, Jonathas Sales de Alencar, Lucas Pereira de Pereira, Vandbergue Santos Lima-Neto, Reginaldo Gonçalves Brilhante, Raimunda Nogueira Sidrim, José Júlio Costa Maia, Débora Castelo Brancode Souza Collares Rocha, Marcos Fábio Gadelha http://repositorio.ufc.br/handle/riufc/45871 2019-09-18T15:48:13Z 2019-06-01T00:00:00Z

Título: Cefepime and amoxicillin increase metabolism and enhance caspofungin tolerance of Candida albicans biofilms Autor(es): Cordeiro, Rossana de Aguiar; Evangelista, Antonio Jose de Jesus; Serpa, Rosana; Andrade, Ana Raquel Colares de; Mendes, Patrícia Bruna Leite; Oliveira, Jonathas Sales de; Alencar, Lucas Pereira de; Pereira, Vandbergue Santos; Lima-Neto, Reginaldo Gonçalves; Brilhante, Raimunda Nogueira; Sidrim, José Júlio Costa; Maia, Débora Castelo Brancode Souza Collares; Rocha, Marcos Fábio Gadelha Abstract: It is well known that prolonged antibiotic therapy alters the mucosal microbiota composition, increasing the risk of invasive fungal infection (IFI) in immunocompromised patients. The present study investigated the direct effect of b-lactam antibiotics cefepime (CEF) and amoxicillin (AMOX) on biofilm production by Candida albicans ATCC 10231. Antibacterials at the peak plasmatic concentration of each drug were tested against biofilms grown on polystyrene surfaces. Biofilms were evaluated for biomass production, metabolic activity, carbohydrate and protein contents, proteolytic activity, ultrastructure, and tolerance to antifungals. CEF and AMOX enhanced biofilm production by C. albicans ATCC 10231, stimulating biomass production, metabolic activity, viable cell counts, and proteolytic activity, as well as increased biovolume and thickness of these structures. Nevertheless, AMOX induced more significant changes in C. albicans biofilms than CEF. In addition, it was shown that AMOX increased the amount of chitin in these biofilms, making them more tolerant to caspofungin. Finally, it was seen that, in response to AMOX, C. albicans biofilms produce Hsp70 – a protein with chaperone function related to stressful conditions. These results may have a direct impact on the pathophysiology of opportunistic IFIs in patients at risk. Tipo: Artigo de Periódico

2019-06-01T00:00:00Z Nacher, Mathieu Leitao, Terezinha Silva Gómez, Beatriz L. Couppié, Pierre Adenis, Antoine Damasceno, Lisandra Serra Demar, Magalie Samayoa, Blanca Cáceres, Diego H. Pradinaud, Roger Sousa, Anastacio de Queiroz Arathoon, Eduardo Restrepo, Angela http://repositorio.ufc.br/handle/riufc/45870 2022-12-16T16:54:24Z 2019-06-01T00:00:00Z

Título: The fight against HIV-associated disseminated histoplasmosis in the americas: unfolding the different stories of four centers Autor(es): Nacher, Mathieu; Leitao, Terezinha Silva; Gómez, Beatriz L.; Couppié, Pierre; Adenis, Antoine; Damasceno, Lisandra Serra; Demar, Magalie; Samayoa, Blanca; Cáceres, Diego H.; Pradinaud, Roger; Sousa, Anastacio de Queiroz; Arathoon, Eduardo; Restrepo, Angela Abstract: Disseminated histoplasmosis is a major opportunistic infection of HIV-infected patients, killing thousands in Latin America each year. Yet, it remains a neglected disease that is often confused with tuberculosis, for lack of simple, affordable, and rapid diagnostic tools. There is great heterogeneity in the level of histoplasmosis awareness. The purpose of this report was to describe how the historical “awakening” to the threat of histoplasmosis came to be in four different centers that have actively described this disease: In Brazil, the Sao José hospital in Fortaleza; in Colombia, the Corporación para Investigaciones Biológicas inMedellin; in French Guiana, Cayenne Hospital; and in Guatemala, the Association de Salud Integral in Guatemala city. In Brazil and French Guiana, the search for leishmaniasis on the buffy coat or skin smears, respectively, led to the rapid realization that HIV patients were suffering from disseminated histoplasmosis. With time and progress in fungal culture, the magnitude of this problem turned it into a local priority. In Colombia and Guatemala, the story is different because for these mycology centers, it was no surprise to find histoplasmosis in HIV patients. In addition, collaborations with the CDC to evaluate antigen-detection tests resulted in researchers and clinicians developing the capacity to rapidly screen most patients and to demonstrate the very high burden of disease in these countries. While the lack of awareness is still a major problem, it is instructive to review the ways through which different centers became histoplasmosis-aware. Nevertheless, as new rapid diagnostic tools are becoming available, their implementation throughout Latin America should rapidly raise the level of awareness in order to reduce the burden of histoplasmosis deaths. Tipo: Artigo de Periódico

2019-06-01T00:00:00Z Fievez, Aline Mireille da Cunha Silva-Freitas, Maria Luciana Queiroz Sousa, Anastácio de Santos-Oliveira, Joanna R. Cruz, Alda M. da http://repositorio.ufc.br/handle/riufc/45869 2019-09-18T15:51:05Z 2019-03-01T00:00:00Z

Título: Lower levels of leptin are associated with severity parameters in visceral leishmaniasis patients Autor(es): Fievez, Aline Mireille da Cunha; Silva-Freitas, Maria Luciana; Queiroz Sousa, Anastácio de; Santos-Oliveira, Joanna R.; Cruz, Alda M. da Abstract: Visceral leishmaniasis (VL) is the most severe clinical form of leishmaniasis, and if untreated may be fatal. It affects important organs of the immune system and is characterized by a specific immunosuppression, along with intense cellular activation and cytokine storm. Moreover, VL is now recognized as a systemic inflammatory response syndrome (SIRS), in which multiple cytokines and other pro-inflammatory molecules are released. The action of these inflammatory mediators may be considered risk factors for poor prognosis and death. Leptin, a hormone derived from adipose tissue, has been described with several immunoregulatory functions in vitro and in vivo Leishmania infection models, particularly for enhancing the macrophage microbicidal mechanisms. Considering that evaluation of immunologic parameters that may be associated with this clinical scenario may help to decrease VL lethality, we evaluated whether leptin is associated with VL pathogenesis. Thirty-one patients were recruited in the active phase of VL, of which 22 were followed up until one month after therapy (1mpt). Except for creatinine levels, all clinical parameters were altered in active VL patients, especially leucocyte counts and albumin and hemoglobin levels. Also, elevated levels of lipopolysaccharide (LPS), immunoglobulins (Ig)G1 and G3 anti-Leishmania and interleukins (IL)-6 and -10 were higher than in healthy individuals. In contrast, active VL patients presented diminished serum leptin levels and positive correlation with leukocytes counts and hemoglobin and albumin levels. After 1mpt, VL patients showed a significant increase in leptin levels, reaching values similar to healthy volunteers. As expected, only LPS levels remained elevated after 1mpt. These findings suggest that leptin levels are affected in Leishmania infection and the correlation with important parameters associated with the prognosis of VL points to the involvement of this molecule in VL immunopathogenesis. Additional studies are needed to evaluate the possibility of leptin as a prognostic marker of VL. Tipo: Artigo de Periódico

2019-03-01T00:00:00Z