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Title in Portuguese: In vitro biological potential of Guanxuma-of-Horn [Sebastiania corniculata (Vahl) Mull. Arg.] in infection control
Author: Silva, Isabelle Souza de Mélo
Santos, Raíssa Fernanda Evangelista Pires dos
Melo, Thiane de Vasconcellos Costa
Silva, Ana Jéssica Cassimiro da
Sarmento, Patrícia de Albuquerque
Lúcio, Ingrid Martins Leite
Campesatto, Eliane Aparecida
Padilha, Francine Ferreira
Conserva, Lucia Maria
Bastos, Maria Lysete de Assis
Keywords: Euphorbiaceae
Testes de Sensibilidade Microbiana
Sobrevivência Celular
Issue Date: 2014
Publisher: Journal of Chemical and Pharmaceutical Research
Citation: SILVA, I. S. de M. et al. In vitro biological potential of Guanxuma-of-Horn [Sebastiania corniculata (Vahl) Mull. Arg.] in infection control. Journal of Chemical and Pharmaceutical Research, Rajasthan, v. 6, n. 4, p. 663-669, 2014.
Abstract: Medicinal plants with antimicrobial properties built into the problem of infection have been investigated, guide the discovery of efficient against the emerging pathogens herbal related to bacterial and fungal infection. This study aimed to enlarge the possibilities of knowledge about antibacterial and antifungal activities of this plant, in the treatment of infections. The results of antimicrobial activity and cytotoxicity of two fractions in MeOH/H2O from ethanol and acetone extracts of guanxuma-of-Horn [Sebastiania corniculata (Vahl) Mull. Arg.] (Euphorbiaceae) evaluated the extracts by disk diffusion test (DD) and the method of the Minimum Inhibitory Concentration (MIC). The extracts were active for Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus pneumoniae, Pseudomonas aeruginosa, Acinectobacter calcoaceticus and Proteus mirabilis in the DD test. However, the best results for these fractions were against P. aeruginosa with an MIC from 250 to 125 μg/mL, respectively. In the evaluation of cytotoxic for cell viability by MTT, only a dose of 100 μg/mL exhibited moderate cytotoxicity with p < 0.0001. In this perspective, the other extracts showed significant cytotoxicity, which suggests further research to evaluate the anti-tumor activity and consolidate the evidence obtained in the research present.
metadata.dc.type: Artigo de Periódico
ISSN: 0975-7384
Appears in Collections:DENF - Artigos publicados em revistas científicas

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