Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/5758
Title in Portuguese: The effects of the brazilian ant Dinoponera quadriceps venom on chemically induced seizure models
Author: Lopes, Kamila Soares
Rios, Emiliano Ricardo Vasconcelos
Lima, Camila Nayane de Carvalho
Linhares, Maria Isabel
Torres, Alba Fabíola Costa
Havt, Alexandre
Quinet, Yves Patric
Fonteles, Marta Maria de França
Martins, Alice Maria Costa
Keywords: Venenos de Formiga
Venenos de Artrópodes
Issue Date: Sep-2013
Publisher: Neurochemistry International
Citation: LOPES, K. S. et al. The effects of the brazilian ant Dinoponera quadriceps venom on chemically induced seizure models. Neurochemistry International, Oxford, Inglaterra, v. 63, n. 3, p. 141-145, set. 2013.
Abstract: Arthropod venoms are potential sources of neuroactive substances, providing new tools for the design of drugs. The aim of this study was to evaluate the effects of Dinoponera quadriceps venom (DqV) on seizure models in mice induced by pentylenetetrazole (PTZ), pilocarpine, and strychnine. In the PTZ model, intraperitoneal treatment with DqV (0.5 mg/kg) increased the time until the first seizure and the percentage of survival (155.4 ± 27.7 s/12.5%, p < 0.05) compared to the control group (79.75 ± 3.97 s/0%), whereas endovenous treatment (0.1 and 0.5 mg/kg) decreased the time until the first seizure (0.1 mg/kg: 77.83 ± 5.3 s versus 101.0 ± 3.3 s in the control group; 0.5 mg/kg: 74.43 ± 3.9 s versus 101.0 ± 3.3 s for the control group, p < 0.05). We did not observe significant changes in the pilocarpine- and strychnine-induced seizure models. In assays that measured oxidative parameters in the PTZ model, intraperitoneal treatment with DqV (0.5 and 2.0 mg/kg) only decreased the levels of MDA and nitrite in the cortex. However, endovenous treatment with DqV (0.1 and 0.5 mg/kg) increased the levels of MDA in the cortex and hippocampus and at a dose of 0.5 mg/kg in the striatum. Moreover, increased in nitrite content was observed in all three of the brain regions analyzed. Taken together, the D. quadriceps venom caused both neuroprotective and neurotoxic effects in a PTZ-induced seizure model, and this effect was dependent on the route of administration used.
URI: http://www.repositorio.ufc.br/handle/riufc/5758
ISSN: 0197-0186
Appears in Collections:DFAR - Artigos publicados em revistas científicas

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