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Title in Portuguese: Mangiferin, a natural xanthone, accelerates gastrointestinal transit in mice involving cholinergic mechanism
Author: Morais, Talita Cavalcante
Lopes, Synara Cavalcante
Carvalho, Karine Maria Martins Bezerra
Arruda, Bruno Rodrigues
Souza, Francisco Thiago Correia de
Trevisan, Maria Teresa Salles
Rao, Vietla Satyanarayana
Santos, Flávia Almeida
Keywords: Conteúdo Gatrointestinal
Issue Date: Jul-2012
Publisher: World Journal of Gastroenterology
Citation: MORAIS, T, C, et al. Mangiferin, a natural xanthone, accelerates gastrointestinal transit in mice involving cholinergic mechanism. World Journal of Gastroenterology, v. 18, n. 25, p. 3207-3214, jul. 2012.
Abstract: AIM: To investigate the effects of mangiferin on gas - trointestinal transit (GIT) in normal and constipated mice, together with the possible mechanism. METHODS: Intragastrically-administered charcoal mea was used to measure GIT in overnight starved Swiss mice. In the first experiments, mangiferin (3 mg/kg, 10 mg/kg, 30 mg/kg, and 100 mg/kg, po ) or tegaserod (1 mg/kg, ip ) were administered 30 min before the char - coal meal to study their effects on normal transit. In the second series, mangiferin (30 mg/kg) was tested on delayed GIT induced by several different pharma - cological agonists (morphine, clonidine, capsaicin) or antagonists (ondansetron, verapamil, and atropine) whereas in the third series, mangiferin (30 mg/kg, 100 mg/kg and 300 mg/kg) or tegaserod (1 mg/kg) were tested on 6 h fecal pellets outputted by freely fed mice. The ratio of wet to dry weight was calculated and used as a marker of fecal water content.
metadata.dc.type: Artigo de Periódico
ISSN: 1007-9327 (print)
2219-2840 (online)
Appears in Collections:DFIFA - Artigos publicados em revista científica

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