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Title in Portuguese: Linalool-rich rosewood oil induces vago-vagal bradycardic and depressor reflex in rats
Author: Siqueira, Rodrigo José de
Rodrigues, Karilane Maria Silvino
Silva, Moisés Tolentino Bento da
Correia Junior, Carlos Antônio Barros
Duarte, Gloria Pinto
Magalhães, Pedro Jorge Caldas
Cunha, Pergentino José Sousa da
Lahlou, Saad
Maia, José Guilherme Soares
Santos, Armênio Aguiar dos
Keywords: Músculo Liso Vascular
Issue Date: Feb-2013
Publisher: Phytotherapy Research
Citation: SIQUEIRA, R. J. de et al. Linalool-rich rosewood oil induces vago-vagal bradycardic and depressor reflex in rats, Phytotherapy Research, London, GB, v. 1, p. 1-7, fev. 2013.
Abstract: Cardiovascular effects of the linalool-rich essential oil of Aniba rosaeodora (here named as EOAR) in normotensive rats were investigated. In anesthetized rats, intravenous (i.v.) injection of EOAR induced dosedependent biphasic hypotension and bradycardia. Emphasis was given to the first phase (phase 1) of the cardiovascular effects, which is rapid (onset time of 1–3 s) and not observed in animals submitted to bilateral vagotomy or selective blockade of neural conduction of vagal C-fibre afferents by perineural treatment with capsaicin. Phase 1 was also absent when EOAR was directly injected into the left ventricle injection, but it was unaltered by i.v. pretreatment with capsazepine, ondansetron or HC030031. In conscious rats, EOAR induced rapid and monophasic hypotensive and bradycardiac (phase 1) effects that were abolished by i.v. methylatropine. In endothelium- intact aortic rings, EOAR fully relaxed phenylephrine-induced contractions in a concentrationdependent manner. The present findings reveal that phase 1 of the bradycardiac and depressor responses induced by EOAR has a vago-vagal reflex origin resulting from the vagal pulmonary afferents stimulation. Such phenomenon appears not to involve the recruitment of C-fibre afferents expressing 5HT3 receptors or the two chemosensory ion channels TRPV1 and TRPA1. Phase 2 hypotensive response appears resulting from a direct vasodilatory action. Copyright © 2013 John Wiley & Sons, Ltd.
ISSN: 0951-418X
Appears in Collections:DFIFA - Artigos publicados em revista científica

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