Please use this identifier to cite or link to this item:
Title in Portuguese: Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats
Author: Azoubel, M.C.F.
Menezes, Adriana Magalhães Andrade
Bezerra, Daniel Pereira
Oriá, Reinaldo Barreto
Ribeiro, Ronaldo de Albuquerque
Brito, Gerly Anne de Castro
Keywords: Perda Óssea Alveolar
Issue Date: Jan-2007
Publisher: Brazilian Journal of Medical and Biological Research
Citation: AZOUBEL, M.C.F. et al. Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, SP, v. 40, n. 1, p. 117-125, 2007.
Abstract: We investigated the effect of etoricoxib, a selective cyclooxygenase- 2 inhibitor, and indomethacin, a non-selective cyclooxygenase inhib- itor, on experimental periodontitis, and compared their gastrointesti- nal side effects. A ligature was placed around the second upper left molars of female Wistar rats (160 to 200 g). Animals (6 per group) were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/kg indomethacin, or 0.2 mL saline, starting 5 days after the induction of periodontitis, when bone resorption was detected, until the sacrifice on the 11th day. The weight and survival rate were monitored. Alveolar bone loss (ABL) was measured as the sum of distances between the cusp tips and the alveolar bone. The gastric mucosa was examined macroscopically and the periodontium and gastric and intestinal mucosa were examined by histopathology. The ongoing ABL was significantly inhibited (P < 0.05) by 3 and 9 mg/kg etoricoxib and by indomethacin: control = 4.08 ± 0.47 mm; etoricoxib (3 mg/kg) = 1.89 ± 0.26 mm; etoricoxib (9 mg/kg) = 1.02 ± 0.14 mm; indometh- acin = 0.64 ± 0.15 mm. Histopathology of periodontium showed that etoricoxib and indomethacin reduced inflammatory cell infiltration, ABL, and cementum and collagen fiber destruction. Macroscopic and histopathological analysis of gastric and intestinal mucosa demon- strated that etoricoxib induces less damage than indomethacin. Ani- mals that received indomethacin presented weight loss starting on the 7th day, and higher mortality rate (58.3%) compared to etoricoxib (0%). Treatment with etoricoxib, even starting when ABL is detected, reduces inflammation and cementum and bone resorption, with fewer gastrointestinal side effects.
metadata.dc.type: Artigo de Periódico
Appears in Collections:DFIFA - Artigos publicados em revista científica

Files in This Item:
File Description SizeFormat 
2007_art_amamenezes.pdf1,16 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.