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Title in Portuguese: Synergistic effects of amiodarone and fluconazole on Candida tropicalis resistant to fluconazole
Author: Silva, Cecília Rocha da
Andrade Neto, João Batista de
Sidrim, José Júlio Costa
Ângelo, Maria Rozzelê Ferreira
Magalhães, Hemerson Iury Ferreira
Cavalcanti, Bruno Coêlho
Brilhante, Raimunda Sâmia Nogueira
Macedo, Danielle Silveira
Moraes Filho, Manoel Odorico de
Lobo, Marina Duarte Pinto
Grangeiro, Thalles Barbosa
Nobre Júnior, Hélio Vitoriano
Keywords: Amiodarona
Candida tropicalis
Issue Date: Apr-2013
Publisher: Antimicrobial Agents and Chemotherapy
Citation: SILVA, C. R. et al. Synergistic effects of amiodarone and fluconazole on Candida tropicalis resistant to fluconazole. Antimicrobial Agents and Chemotherapy, Bethesda, v. 57, n. 4, p. 1691-1700, abr. 2013.
Abstract: There have recently been significant increases in the prevalence of systemic invasive fungal infections. However, the number of antifungal drugs on the market is limited in comparison to the number of available antibacterial drugs. This fact, coupled with the increased frequency of cross-resistance, makes it necessary to develop new therapeutic strategies. Combination drug thera- pies have become one of the most widely used and effective strategies to alleviate this problem. Amiodarone (AMD) is classically used for the treatment of atrial fibrillation and is the drug of choice for patients with arrhythmia. Recent studies have shown broad antifungal activity of the drug when administered in combination with fluconazole (FLC). In the present study, we in- duced resistance to fluconazole in six strains of Candida tropicalis and evaluated potential synergism between fluconazole and amiodarone. The evaluation of drug interaction was determined by calculating the fractional inhibitory concentration and by performing flow cytometry. We conclude that amiodarone, when administered in combination with fluconazole, exhibits activ- ity against strains of C. tropicalis that are resistant to fluconazole, which most likely occurs via changes in the integrity of the yeast cell membrane and the generation of oxidative stress, mitochondrial dysfunction, and DNA damage that could lead to cell death by apoptosis.
metadata.dc.type: Artigo de Periódico
ISSN: 0066-4804
Appears in Collections:DMC - Artigos publicados em revistas científicas

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