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Title in Portuguese: Pharmacological characterization and raman spectroscopy evaluation of oral and maxillofacial surgery-related Carnoy´s olution odified by ifferent viscosity agents
Author: Carvalho, Francisco Samuel Rodrigues
Verde, Marina Mota Lima
Viana, Khalil Fernandes
Bezerra, Thâmara Manoela Marinho
Fonseca, Said Gonçalves da Cruz
Pereira, Karuza Maria Alves
Ribeiro, Thyciana Rodrigues
Costa, Fábio Wildson Gurgel
Keywords: Análise Espectral Raman
Spectrum Analysis, Raman
Cirurgia Bucal
Surgery, Oral
Issue Date: 2019
Publisher: Asian Pacific Journal of Cancer Prevention
Citation: CARVALHO, Francisco Samuel Rodrigues et al. Pharmacological characterization and raman spectroscopy evaluation of oral and maxillofacial surgery-related Carnoy´s olution odified by ifferent viscosity agents. Asian Pacific Journal of Cancer Prevention, v. 20, p. 3335-39, 2019.
Abstract: Background: There are several lesions of odontogenic and non-odontogenic origin in the oral cavity, such as odontogenic keratocyst, as well as many treatment options for such lesions. In order to reduce recurrence due to conservative treatments and less aesthetic and functional impairment of the patient (radical therapies), Carnoy’s solution has been used as an adjuvant to surgery, showing satisfactory results. Its application is not standardized, presenting risks to adjacent tissues. Thus, we characterized the Carnoy’s solution with different viscosity agents to enhance its applicability. Material and Methods: All solutions prepared (Carnoy with and without chloroform) were added with viscosity agent: ethyl cellulose, propylene glycol, and glycerol totaling eight solutions. The pharmacological characterization of the solutions was performed by determining the mass density and relative density (using a clean and dry pycnometer), pH (using pH meter), and concentration of Fe3+ (using ultraviolet/visible spectroscopy). The analyses of the inorganic components were determined by Raman micro spectrometry. Data were analyzed with statistical program BIOESTAT 5.3. Results: Solutions with ethyl cellulose were discarded due to precipitate formation and suspension of the viscosity agent. In the other solutions, viscosity increase (propylene glycol solutions) and acidic pH were observed mainly in the glycerol group. The ferric chloride characterized as a hemostatic agent had its concentration increased with the use of thickening agents, theoretically favoring its action. Conclusion: The similarity of the propylene glycol and glycerol molecules justifies the Raman spectra of these substances to be similar and the difficulty in obtaining a “fingerprint”.
metadata.dc.type: Artigo de Periódico
ISSN: 1513-7368
2476-762X (On line)
Appears in Collections:DCOD - Artigos publicados em revistas científicas

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