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Tipo:	Artigo de Periódico
Título:	Histoplasmosis in HIV-positive patients in Ceará, Brazil : clinical-laboratory aspects and in vitro antifungal susceptibility of Histoplasma capsulatum isolates
Autor(es):	Caetano, Erica Pacheco Brilhante, Raimunda S.N. Fechine, Maria A.B. Mesquita, Jacó R.L. Cordeiro, Rossana A. Rocha, Marcos F.G. Monteiro, André J. Lima, Rita A.C. Pereira, Juliana F. Castelo-Branco, Débora S.C.M. Camargo, Zoilo Pires de Sidrim, José J.C.
Palavras-chave:	HIV;Histoplasmose;Histoplasma
Data do documento:	Ago-2012
Instituição/Editor/Publicador:	Transactions of the Royal Society of Tropical Medicine and Hygiene
Citação:	CAETANO, É. P. et al. Histoplasmosis in HIV-positive patients in Ceará, Brazil : clinical-laboratory aspects and in vitro antifungal susceptibility of Histoplasma capsulatum isolates. Transactions of the Royal Society of Tropical Medicine and Hygiene, Oxford, v. 106, n. 8, p. 484-88, ago. 2012.
Resumo:	This study contains a descriptive analysis of histoplasmosis in AIDS patients between 2006 and 2010 in the state of Ceará, Brazil. Additionally, the in vitro susceptibility of Histoplasma capsulatum isolates obtained during this period was assessed. We report 208 cases of patients with histoplasmosis and AIDS, describing the epidemiological, clinical, laboratory and therapeutic aspects. The in vitro antifungal susceptibility test was carried out by the microdilution method, according to Clinical and Laboratory Standards Institute, with H. capsulatum in the filamentous and yeast phases, against the antifungals amphotericin B, fluconazole, itraconazole, voriconazole and caspofungin. In 38.9% of the cases, histoplasmosis was the first indicator of AIDS and in 85.8% of the patients the CD4 cell count was lower than 100 cells/mm3. The lactate dehydrogenase levels were high in all the patients evaluated, with impairment of hepatic and renal function and evolution to death in 42.3% of the cases. The in vitro susceptibility profile demonstrated there was no antifungal resistance among the isolates evaluated. There was a significant increase in the number of histoplasmosis cases in HIV-positive patients during the period surveyed in the state of Ceará, northeastern Brazil, but no antifungal resistance among the recovered isolates of H. capsulatum.
URI:	http://www.repositorio.ufc.br/handle/riufc/4949
ISSN:	0035-9203
Aparece nas coleções:	DMC - Artigos publicados em revistas científicas

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