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dc.contributor.authorCordeiro, Rossana de Aguiar-
dc.contributor.authorEvangelista, Antonio Jose de Jesus-
dc.contributor.authorSerpa, Rosana-
dc.contributor.authorAndrade, Ana Raquel Colares de-
dc.contributor.authorMendes, Patrícia Bruna Leite-
dc.contributor.authorOliveira, Jonathas Sales de-
dc.contributor.authorAlencar, Lucas Pereira de-
dc.contributor.authorPereira, Vandbergue Santos-
dc.contributor.authorLima-Neto, Reginaldo Gonçalves-
dc.contributor.authorBrilhante, Raimunda Nogueira-
dc.contributor.authorSidrim, José Júlio Costa-
dc.contributor.authorMaia, Débora Castelo Brancode Souza Collares-
dc.contributor.authorRocha, Marcos Fábio Gadelha-
dc.identifier.citationCORDEIRO, Rossana de Aguiar et al. Cefepime and amoxicillin increase metabolism and enhance caspofungin tolerance of Candida albicans biofilms. Front. Microbiol., v. 10, p. 1-9, jun. 2019.pt_BR
dc.description.abstractIt is well known that prolonged antibiotic therapy alters the mucosal microbiota composition, increasing the risk of invasive fungal infection (IFI) in immunocompromised patients. The present study investigated the direct effect of b-lactam antibiotics cefepime (CEF) and amoxicillin (AMOX) on biofilm production by Candida albicans ATCC 10231. Antibacterials at the peak plasmatic concentration of each drug were tested against biofilms grown on polystyrene surfaces. Biofilms were evaluated for biomass production, metabolic activity, carbohydrate and protein contents, proteolytic activity, ultrastructure, and tolerance to antifungals. CEF and AMOX enhanced biofilm production by C. albicans ATCC 10231, stimulating biomass production, metabolic activity, viable cell counts, and proteolytic activity, as well as increased biovolume and thickness of these structures. Nevertheless, AMOX induced more significant changes in C. albicans biofilms than CEF. In addition, it was shown that AMOX increased the amount of chitin in these biofilms, making them more tolerant to caspofungin. Finally, it was seen that, in response to AMOX, C. albicans biofilms produce Hsp70 – a protein with chaperone function related to stressful conditions. These results may have a direct impact on the pathophysiology of opportunistic IFIs in patients at risk.pt_BR
dc.publisherFrontiers in Microbiologypt_BR
dc.subjectAnti-Bacterial Agentspt_BR
dc.subjectCandida albicanspt_BR
dc.titleCefepime and amoxicillin increase metabolism and enhance caspofungin tolerance of Candida albicans biofilmspt_BR
dc.typeArtigo de Periódicopt_BR
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