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Title in Portuguese: Protective Effect of cashew gum (Anacardium occidentale L.) on 5-Fluorouracil-induced intestinal mucositis
Author: Miranda, João Antônio Leal de
Barreto, João Erivan Façanha
Martins, Dainesy Santos
Pimentel, Paulo Vitor de Souza
Costa, Deiziane Viana da Silva
Silva, Reyca Rodrigues e
Souza, Luan Kelves Miranda de
Lima, Camila Nayane de Carvalho
Rocha, Je erson Almeida
Freitas, Ana Paula Fragoso de
Silva, Durcilene Alves da
Scafuri, Ariel Gustavo
Leitão, Renata Ferreira de Carvalho
Brito, Gerly Anne de Castro
Medeiros, Jand Venes Rolim
Cerqueira, Gilberto Santos
Keywords: Mucosite
Anacardium occidentale
Issue Date: Apr-2019
Publisher: Pharmaceuticals
Citation: MIRANDA, João Antônio Leal de et al. Protective Effect of cashew gum (Anacardium occidentale L.) on 5-Fluorouracil-induced intestinal mucositis. Pharmaceuticals, v. 12, n. 2, p. 1-17, apr. 2019.
Abstract: Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Cashew gum (CG) has been reported as a potent anti-inflammatory agent. In the present study, we aimed to evaluate the e ect of CG extracted from the exudate of Anacardium occidentale L. on experimental intestinal mucositis induced by 5-FU. Swiss mice were randomly divided into seven groups: Saline, 5-FU, CG 30, CG 60, CG 90, Celecoxib (CLX), and CLX + CG 90 groups. The weight of mice was measured daily. After treatment, the animals were euthanized and segments of the small intestine were collected to evaluate histopathological alterations (morphometric analysis), levels of malondialdehyde (MDA), myeloperoxidase (MPO), and glutathione (GSH), and immunohistochemical analysis of interleukin 1 beta (IL-1 ) and cyclooxygenase-2 (COX-2). 5-FU induced intense weight loss and reduction in villus height compared to the saline group. CG 90 prevented 5-FU-induced histopathological changes and decreased oxidative stress through decrease ofMDAlevels and increase of GSH concentration. CG attenuated inflammatory process by decreasing MPO activity, intestinal mastocytosis, and COX-2 expression. Our findings suggest that CG at a concentration of 90 mg/kg reverses the e ects of 5-FU-induced intestinal mucositis.
metadata.dc.type: Artigo de Periódico
ISSN: 1424-8247 (On line)
Appears in Collections:DMO - Artigos publicados em revistas científicas

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