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Title in Portuguese: Gum arabic and red propolis protecteting colorectal preneoplastic lesions in a rat model of azoxymethane
Author: Braga, Vanessa Nogueira Lages
Juanes, Camila de Carvalho
Peres Júnior, Hélio de Souza
Sousa, José Robson de
Cavalcanti, Bruno Coêlho
Jamacaru, Francisco Vagnaldo Fechine
Lemos, Telma Leda Gomes de
Dornelas, Conceição Aparecida
Keywords: Própole
Issue Date: Feb-2019
Publisher: Acta Cirurgica Brasileira
Citation: BRAGA, Vanessa Nogueira Lages et al. Gum arabic and red propolis protecteting colorectal preneoplastic lesions in a rat model of azoxymethane. Acta Cir. Bras., São Paulo, v. 34, n. 2, feb., 2019.
Abstract: Purpose: To evaluate red propolis, gum arabic and L-lysine activity on colorectal preneoplastic lesions induced by azoxymethane (AOM). Methods: The study featured 4 control groups (I-IV) and 4 experimental groups (V-VIII), totaling 48 rats. Once a week for 2 weeks, animals on control groups received saline, while animals in experimental groups received azoxymethane (15 mg/kg i.p.). The follow up along 16 weeks included daily oral gavage to administer water (I and V), L-lysine (150 mg/kg)(II and VI), própolis (100mg/5ml/kg)(III and VII), or gum arabic (5ml/kg)(IV and VIII). Was performed surgery on the animals in the end of this time in order to collect blood for biological assays (TBARS, GSH), followed by their sacrifice to tissue extract. Results: Oxidative stress (TBARS) and the number of aberrant crypt foci (ACF) in distal colon were lower using própolis (p<0.01 for both parameters). Gum arabic reduced preneoplastic lesions (ACF ≤ 4 crypts) on distal colon and on the entire colon (p<0.05). Conclusions: Red propolis reduced AOM-induced oxidative stress (TBARS) and total number of ACF in the distal colon. L-lysine neither protected against nor enhanced AOM-induced ACF. Gum arabic reduced the number of ACF.
metadata.dc.type: Artigo de Periódico
ISSN: Print 0102-8650
On-line 1678-2674
Appears in Collections:PPGF - Artigos publicados em revistas científica

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