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Title in Portuguese: Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass
Author: Machado, Francisco Heine Ferreira
Castro Filho, Heladio Feitosa de
Babadopulos, Rodrigo Feitosa de Albuquerque Lima
Rocha, Hermano Alexandre Lima
Rocha, José Lima de Carvalho
Moraes Filho, Manoel Odorico de
Keywords: Obesidade
Cirurgia Bariátrica
Bariatric Surgery
Cálculos Biliares
Issue Date: Feb-2019
Publisher: Acta Cirurgica Brasileira
Citation: Machado, Francisco Heine Ferreira et al. Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass. Acta Cir. Bras., São Paulo, v. 34, n.1, feb. 2019.
Abstract: Purpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation. Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). The patients were followed-up, and ultrasonography was performed to determine the presence of gallstones at various times during followup. Demographic, anthropometric and comorbid indicators were obtained. The data were subjected to normality tests and evaluated using appropriate tests. Results: Patients did not differ in their baseline characteristics. Of the 69 patients who used UDCA, only one patient developed cholelithiasis (1%), whereas 18 controls (26%) formed gallstones (OR = 24.4, p <0.001). Also, other factors were found not to influence the formation of calculi, such as pre-operative or postoperative hepatic steatosis or diabetes (p = 0.759, 0.468, 0.956). Conclusion: The results demonstrated that patients who did not use UDCA showed a 24.4- fold greater probability of developing cholelithiasis.
metadata.dc.type: Artigo de Periódico
ISSN: Print 0102-8650
On-line 1678-2674
Appears in Collections:PPGF - Artigos publicados em revistas científica

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