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Title in Portuguese: Immunohistochemical evaluation of GLUT-3 and GLUT-4 in oral epithelial dysplasia and oral squamous cell carcinoma
Author: Feitosa, Sthefane Gomes
Viana, Khalil Fernandes
Luna, Ealber Carvalho Macedo
Costa, Fábio Wildson Gurgel
Cavalcante, Roberta Barroso
Chaves, Filipe Nobre
Chaves, Hellíada Vasconcelos
Pereira, Karuza Maria Alves
Keywords: Carcinoma de Células Escamosas
Carcinoma, Squamous Cell
Glucose Transport Proteins, Facilitative
Proteínas Facilitadoras de Transporte de Glucose
Issue Date: Jul-2018
Publisher: Asian Pacific Journal of Cancer Prevention
Citation: FEITOSA, S. G. et al. Immunohistochemical evaluation of GLUT-3 and GLUT-4 in oral epithelial dysplasia and oral squamous cell carcinoma. Asian Pacific Journal of Cancer Prevention, v. 19, n. 7, p. 1779-1783, 2018.
Abstract: Objectives: To evaluate immunohistochemically the expression of GLUT-3 and GLUT-4 in oral epithelial dysplasia (OED) and the oral squamous cell carcinoma (OSCC) and assess possible involvement in the malignant transformation of oral lesions. Methods: Tissue samples of 15 cases of OSCC and 15 of OED were subjected to immunohistochemistry with anti-GLUT-3 and anti-GLUT-4 antibodies. Five fields of each case were analyzed, to provide percentages of positive cells at 400X magnification. Result: GLUT-3 and GLUT-4 were positive in 100% of the analyzed samples, the percentage immunolabeling for GLUT-3 ranging from 19% to 73% in the OED group and 10% to 89% in the OSCC group. Positive immunolabeling for GLUT-4 ranged from 15.2% to 79.9% in the OSCC group and 27.1% to 92.6% in the OED group. Statistical analysis with the Mann-Whitney test revealed that there was a higher expression of GLUT-4 in the OED group than in the OSCC group (p=0.04) without any significant difference in the GLUT-3 expression (p=0.852). Conclusion: GLUT-4 expression may indicate some role in oncogenic mechanisms which can determine a malignant phenotype. Thus, it is suggested that further studies on the role of GLUT-3 in oral carcinogenesis be conducted.
metadata.dc.type: Artigo de Periódico
ISSN: 1513-7368
Appears in Collections:DCOD - Artigos publicados em revistas científicas

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