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Title in Portuguese: Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model
Author: Melo, Nayanna de Oliveira Ramos
Juanes, Camila de Carvalho
Alves, Mayara Freire de Alencar
Silva, Emiliano Tiago Melo
Jamacaru, Francisco Vagnaldo Fechine
Lemos, Telma Leda Gomes de
Dornelas, Conceição Aparecida
Keywords: Inibidores da Angiogênese
Angiogenesis Inhibitors
Issue Date: May-2018
Publisher: Acta Cirurgica Brasileira
Citation: MELO, N. de O. R. et al. Effect of red propolis on hamster cheek pouch angiogenesis in a new sponge implant model. Acta Cirurgica Brasileira, São Paulo, v. 33, n. 5, may. 2018.
Abstract: Purpose: To evaluate the effects of red propolis on cheek pouch angiogenesis in a hamster new model sponge implant. Methods: Forty eight animals divided into eight groups. (Groups I-IV), the animals were treated for 15 days before and 10 days after sponge implantation. (Groups V-VIII), the animals were treated for 10 days after sponge implantation (GI and GV: red propolis 100 mg/kg, GII and GVI: celecoxib 20 mg/kg, GIII and GVII: 1% gum arabic 5 mL/kg, GIV and GVIII: distilled water 5 mL/kg). On the 11th day of implantation, the animals were anesthetized for stereoscopic microscopic imaging and morphometric quantification of angiogenesis (SQAN), followed by histopathological evaluation (H&E). Results: In the SQAN analysis, no significant difference was found between the groups. However, on histology, propolis was found reduce the population of mastocytes in the qualitative analyses (p = 0,013) in the quantitative analyses to reduce the number of blood vessels (p = 0,007), and increase the macrophage count (p = 0,001). Conclusion: Red propolis inhibited inflammatory angiogenesis when administered before andcontinuously after sponge implant, and was shown to have immunomodulating effects on inflammatory cells (mastocytes and macrophages) in a new sponge implant hamster model.
URI: 1678-2674 On-line
metadata.dc.type: Artigo de Periódico
ISSN: 0102-8650 Print
Appears in Collections:PPGF - Artigos publicados em revistas científica

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