Please use this identifier to cite or link to this item:
Title in Portuguese: Imaging genetics paradigms in depression research: systematic review and meta-analysis
Author: Pereira, Lícia P.
Köhler, Cristiano A.
Stubbs, Brendon
Miskowiak, Kamilla W.
Morris, Gerwyn
Freitas, Bárbara P. de Freitas
Thompson, Trevor
Fernandes, Brisa S.
Brunoni, André R.
Maes, Michael
Pizzagalli, Diego A.
Carvalho, André F.
Keywords: Depressão
Imagem por Ressonância Magnética
Magnetic Resonance Imaging
Issue Date: Aug-2018
Publisher: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Citation: PEREIRA, L. P. et al. Imaging genetics paradigms in depression research: systematic review and meta-analysis. Progress in Neuro-Psychopharmacology and Biological Psychiatry, v. 86, p. 102-113, aug. 2018.
Abstract: Imaging genetics studies involving participants with major depressive disorder (MDD) have expanded. Nevertheless, findings have been inconsistent. Thus, we conducted a systematic review and meta-analysis of imaging genetics studies that enrolled MDD participants across major databases through June 30th, 2017. Sixtyfive studies met eligibility criteria (N=4034 MDD participants and 3293 controls), and there was substantial between-study variability in the methodological quality of included studies. However, few replicated findings emerged from this literature with only 22 studies providing data for meta-analyses (882 participants with MDD and 616 controls). Total hippocampal volumes did not significantly vary in MDD participants or controls carrying either the BDNF Val66Met ‘Met’ (386 participants with MDD and 376 controls) or the 5-HTTLPR short ‘S’ (310 participants with MDD and 230 controls) risk alleles compared to non-carriers. Heterogeneity across studies was explored through meta-regression and subgroup analyses. Gender distribution, the use of medications, segmentation methods used to measure the hippocampus, and age emerged as potential sources of heterogeneity across studies that assessed the association of 5-HTTLPR short ‘S’ alleles and hippocampal volumes. Our data also suggest that the methodological quality of included studies, publication year, and the inclusion of brain volume as a covariate contributed to the heterogeneity of studies that assessed the association of the BDNF Val66Met ‘Met’ risk allele and hippocampal volumes. In exploratory voxel-wise meta-analyses, MDD participants carrying the 5-HTTLPR short ‘S’ allele had white matter microstructural abnormalities predominantly in the corpus callosum, while carriers of the BDNF Val66Met ‘Met’ allele had larger gray matter volumes and hyperactivation of the right middle frontal gyrus compared to non-carriers. In conclusion, few replicated findings emerged from imaging genetics studies that included participants with MDD. Nevertheless, we explored and identified specific sources of heterogeneity across studies, which could provide insights to enhance the reproducibility of this emerging field.
metadata.dc.type: Artigo de Periódico
ISSN: 0278-5846
1878-4216 (On line)
Appears in Collections:DSC - Artigos publicados em revista científica

Files in This Item:
File Description SizeFormat 
2018_art_lppereira.pdf825,41 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.