Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/32402
Title in Portuguese: Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis
Author: Chu, Che-Sheng
Tseng, Ping-Tao
Stubbs, Brendon
Chen, Tien-Yu
Tang, Chia-Hung
Li, Dian-Jeng
Yang, Wei-Cheng
Chen, Yen-Wen
Wu, Ching-Kuan
Veronese, Nicola
Carvalho, Andre F.
Fernandes, Brisa S.
Herrmann, Nathan
Lin, Pao-Yen
Keywords: Inibidores de Hidroximetilglutaril-CoA Redutases
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Dementia
Demência
Issue Date: Apr-2018
Publisher: Scientific Reports
Citation: CHU, C.-S. et al. Use of statins and the risk of dementia and mild cognitive impairment: a systematic review and meta-analysis. Scientific Reports, 8:5804, apr. 2018.
Abstract: We conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer’s disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27th, 2017 for studies investigating use of statins and incident cognitive decline in adults. Random-effects metaanalyses calculating relative risks (RRs) were conducted to synthesize effect sizes of individual studies. Twenty-five studies met eligibility criteria. Use of statins was significantly associated with a reduced risk of all-caused dementia (k = 16 studies, adjusted RR (aRR) = 0.849, 95% CI = 0.787–0.916, p = 0.000), AD (k = 14, aRR = 0.719, 95% CI = 0.576–0.899, p = 0.004), and MCI (k = 6, aRR = 0.737, 95% CI = 0.556– 0.976, p = 0.033), but no meaningful effects on incident VaD (k = 3, aRR = 1.012, 95% CI = 0.620–1.652, p = 0.961). Subgroup analysis suggested that hydrophilic statins were associated with reduced risk of all-caused dementia (aRR = 0.877; CI = 0.818–0.940; p = 0.000) and possibly lower AD risk (aRR = 0.619; CI = 0.383–1.000; p = 0.050). Lipophilic statins were associated with reduced risk of AD (aRR = 0.639; CI = 0.449–0.908; p = 0.013) but not all-caused dementia (aRR = 0.738; CI = 0.475–1.146; p = 0.176). In conclusion, our meta-analysis suggests that the use of statins may reduce the risk of all-type dementia, AD, and MCI, but not of incident VaD.
URI: http://www.repositorio.ufc.br/handle/riufc/32402
metadata.dc.type: Artigo de Periódico
ISSN: 2045-2322
2045-2322 (On line)
Appears in Collections:DSC - Artigos publicados em revista científica

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