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dc.contributor.authorChaves, Hellíada Vasconcelos-
dc.contributor.authorVal, Danielle Rocha do-
dc.contributor.authorRibeiro, Kátia Alves-
dc.contributor.authorLemos, Jonas Cavalcante-
dc.contributor.authorSouza, Ricardo Basto-
dc.contributor.authorGomes, Francisco Isaac Fernandes-
dc.contributor.authorCunha, Rodrigo Maranguape Silva da-
dc.contributor.authorPinto, Vicente de Paulo Teixeira-
dc.contributor.authorCristino Filho, Gerardo-
dc.contributor.authorSouza, Marcellus Henrique Loiola Ponte de-
dc.contributor.authorBezerra, Mirna Marques-
dc.contributor.authorBrito, Gerly Anne de Castro-
dc.identifier.citationCHAVES, H. V. et al. Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels. Inflammation Research, Basel, p. 1-16, jan. 2018.pt_BR
dc.identifier.issn1023-3830 (Print)-
dc.identifier.issn1420-908X (Online)-
dc.descriptionCHAVES, Hellíada Vasconcelospt_BR
dc.description.abstractObjective and design To investigate the role of heme oxygenase-1 (HO-1), carbon monoxide (CO), and biliverdin (BVD) in the zymosan-induced TMJ arthritis in rats. Materials and Methods Mechanical threshold was assessed before and 4 h after TMJ arthritis induction in rats. Cell influx, myeloperoxidase activity, and histological changes were measured in the TMJ lavages and tissues. Trigeminal ganglion and periarticular tissues were used for HO-1, TNF-α, and IL-1β mRNA time course expression and immunohistochemical analyses. Hemin (0.1, 0.3, or 1 mg kg−1), DMDC (0.025, 0.25, or 2.5 µmol kg−1), biliverdin (1, 3, or 10 mg kg−1), or ZnPP-IX (1, 3 or 9 mg kg−1) were injected (s.c.) 60 min before zymosan. ODQ (12.5 µmol kg−1; s.c.) or glibenclamide (10 mg kg−1; i.p.) was administered 1 h and 30 min prior to DMDC (2.5 µmol kg−1; s.c), respectively. Results Hemin (1 mg kg−1), DMDC (2.5 µmol kg−1), and BVD (10 mg kg−1) reduced hypernociception and leukocyte migration, which ZnPP (3 mg kg−1) enhanced. The effects of DMDC were counteracted by ODQ and glibenclamide. The HO-1, TNF-α, and IL-1β mRNA expression and immunolabelling increased. Conclusions HO-1/BVD/CO pathway activation provides anti-nociceptive and anti-inflammatory effects on the zymosan-induced TMJ hypernociception in rats.pt_BR
dc.publisherInflammation Researchpt_BR
dc.subjectArticulação Temporomandibularpt_BR
dc.subjectTemporomandibular Jointpt_BR
dc.titleHeme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channelspt_BR
dc.typeArtigo de Periódicopt_BR
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