O uso da expressão de CD64 nos neutrófilos como marcador de severidade do eritema nodoso hansênico

Abstract

Objectives: To provide updated information on the new classification scale of erythema nodosum leprosum , as well as on the use of CD64 as a marker of the severity of this reaction. Methods: A n integrative review was performed in the Virtual Health Library and Pubmed with the descriptors erythema nodosum, leprosy, CD4, n e utrophils and severity, where 23 studies were selected. R esults : A classification scale of erythema nodosum leprosum was validated and contains 10 items, being able to differentiate mild to moderate / severe and CD64 expression in neutrophils is elevated in patients with erythema nodosum leprosum, possibly related to the severity of the disease. Conclusion: The new severity scale will facilitate patient evaluation as well as new research. Determination of CD64 expression on neutrophils may be a new method for measuring the prognosis of th ese patients, although more studies are still needed.