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Title in Portuguese: Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial e ffects of antidepressant drugs for antidepressant e ffectiveness
Author: Macedo, Danielle
Chaves Filho, Adriano José Maia
Sousa, Caren Nádia Soares de
Quevedo, João
Barichello, Tatiana
Nobre Júnior, Hélio Vitoriano
Lucena, David Freitas de
Keywords: Antidepressivos
Antidepressive Agents
Issue Date: Jan-2017
Publisher: Journal of Affective Disorders
Citation: MACEDO, D. et al. Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness. Journal of Affective Disorders, Amsterdam, v. 208, p. 22-32, jan. 2017.
Abstract: Objectives The first drug repurposed for the treatment of depression was the tuberculostatic iproniazid. At present, drugs belonging to new classes of antidepressants still have antimicrobial effects. Dysbiosis of gut microbiota was implicated in the development or exacerbation of mental disorders, such as major depressive disorder (MDD). Based on the current interest in the gut-brain axis, the focus of this narrative review is to compile the available studies regarding the influences of gut microbiota in behavior and depression and to show the antimicrobial effect of antidepressant drugs. A discussion regarding the possible contribution of the antimicrobial effect of antidepressant drugs to its effectiveness/resistance is included. Methods The search included relevant articles from PubMed, SciELO, LILACS, PsycINFO, and ISI Web of Knowledge. Results MDD is associated with changes in gut permeability and microbiota composition. In this respect, antidepressant drugs present antimicrobial effects that could also be related to the effectiveness of these drugs for MDD treatment. Conversely, some antimicrobials present antidepressant effects. Conclusion Both antidepressants and antimicrobials present neuroprotective/antidepressant and antimicrobial effects. Further studies are needed to evaluate the participation of antimicrobial mechanisms of antidepressants in MDD treatment as well as to determine the contribution of this effect to antidepressant resistance.
metadata.dc.type: Artigo de Periódico
ISSN: 0165-0327
1573-2517 (On line)
Appears in Collections:DFAR - Artigos publicados em revistas científicas

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