Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/29458
Title in Portuguese: Preheating of urine improves the specificity of urinary cryptococcal antigen testing using the lateral flow assay
Author: Brito-Santos, Fábio
Ferreira, Marcela de Faria
Trilles, Luciana
Muniz, Mauro de Medeiros
Santos, Valdiléa Gonçalves Veloso dos
Carvalho-Costa, Filipe Anibal
Meyer, Wieland
Wanke, Bodo
Lazéra, Márcia dos Santos
Keywords: Diagnóstico Precoce
Early Diagnosis
Criptococose
Cryptococcosis
Issue Date: May-2017
Publisher: PLoS Neglected Tropical Diseases
Citation: BRITO-SANTOS, F. et. Preheating of urine improves the specificity of urinary cryptococcal antigen testing using the lateral flow assay. PLoS Neglected Tropical Diseases, v. 11, p. 1-4, 2017.
Abstract: A delay in laboratory diagnosis is related to sequelae and death. Thus, early diagnosis is the key to decrease the high lethality rate due to cryptococcosis. The cryptococcal antigen lateral flow assay (CrAg LFA) Immy test is standardized for a fast screening point-of-care test for cryptococcosis, detecting cryptococcal antigen in serum and cerebrospinal fluid (CSF). Urine screening would be ideal as a noninvasive approach, but previous studies have shown that fresh urine present false positive results. For this reason, we introduced just one simple physical procedure (i.e, heating of fresh urine prior to CrAg LFA Immy testing) to increase the specificity without compromising test sensitivity.
URI: http://www.repositorio.ufc.br/handle/riufc/29458
ISSN: 1935-2727
1935-2735 (On line)
Appears in Collections:DPML - Artigos publicados em revista científica

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