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|Título:||Early life experience contributes to the developmental programming of depressive-like behaviour, neuroinflammation and oxidative stress|
|Autor(es):||Réus, Gislaine Z.|
Fernandes, Gabrielly C.
Moura, Airam B. de
Silva, Ritele H.
Darabas, Ana Caroline
Souza, Thays G. de
Abelaira, Helena M.
Macêdo, Danielle S.
Transtorno Depressivo Maior
Depressive Disorder, Major
|Data do documento:||Dez-2017|
|Editor:||Journal of Psychiatric Research|
|Citação:||RÉUS, G. Z. ; FERNANDES, G. C. ; MOURA, A. B. ; SILVA, R. H. ; DARABAS, A. C. ; SOUZA, T. G. ; ABELAIRA, H. M. ; CARNEIRO, C. ; WENDHAUSEN, D. ; MICHELS, M. ; PESCADOR, B. ; DAL-PIZZOL, F. ; MACÊDO, D. S. ; QUEVEDO, J. (2017)|
|Abstract:||This study used an animal model of depression induced by maternal care deprivation (MCD) to investigate whether depressive behaviour, neuroinflammation and oxidative stress were underlying factors in developmental programming after early life stress. At postnatal days (PND) 20, 30, 40, and 60, individual subsets of animals were evaluated in behavioural tests and then euthanized to assess cytokine levels and oxidative stress parameters in the prefrontal cortex (PFC), hippocampus and serum. The results showed that MCD did not induce behavioural changes at PND 30 and 40. However, at PND 20 and 60, the rats displayed a depressive-like behaviour in the forced swimming test, without changes in locomotor spontaneous activity. In the brain and serum, the levels of pro-inflammatory cytokines (interleukin-1b (IL-1b), interleukin-6 (IL-6) and tumour necrosis factor-a (TNF-a)) were increased, and the antiinflammatory cytokine (interleukin-10) level was reduced throughout developmental programming (PND 20, 30, 40 and 60). Protein carbonyl levels increased in the brain at PND 30, 40 and 60. Superoxide dismutase (SOD) activity was decreased during all developmental programming phases evaluated in the brain. Catalase (CAT) activity was decreased at PND 20, 40 and 60 in the brain. Our results revealed that “critical episodes” in early life stressful events are able to induce behavioural alterations that persist into adulthood and can stimulate inflammation and oxidative damage in both central and peripheral systems, which are required for distinct patterns of resilience against psychiatric disorders later in life.|
|Descrição:||RÉUS, Gislaine Z. et al. Early life experience contributes to the developmental programming of depressive-like behaviour, neuroinflammation and oxidative stress. Journal of Psychiatric Research, Oxford, v. 95, p. 196-207, dec. 2017.|
1879-1379 (on line)
|Aparece nas coleções:||DFIFA - Artigos publicados em revista científica|
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