Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/26499
Title in Portuguese: Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age
Author: Macedo, Alexandre Casimiro de
Cunha Jr., José Evandro
Yaochite, Juliana Navarro Ueda
Tavares, Clodis Maria
Nagao-Dias, Nagao-DiasAparecida Tiemi
Keywords: Hanseníase
Leprosy
Mycobacterium leprae
Issue Date: Sep-2017
Publisher: Brazilian Journal of Infectious Diseases
Citation: MACEDO, A. C. de et al. Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age. Brazilian Journal of Infectious Diseases, Salvador, v. 21, n. 5, p. 551-561, set./oct. 2017.
Abstract: Considering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4–16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alagoas State – Brazil. Salivary anti-PGL-1 antibodies were quantified by modified ELISA method. The frequency of contact and clinical form of the index case were significantly associated with salivary antibody levels. High frequency of IgM positivity strongly suggests active transmission of M. leprae in these communities. We suggest in the present work that salivary anti-PGL IgA and IgM are important biomarkers to be used for identifying communities with probable active transmission of M. leprae.
URI: http://www.repositorio.ufc.br/handle/riufc/26499
metadata.dc.type: Artigo de Periódico
ISSN: (Online) 1678-4391
(Impresso) 1413-8670
Appears in Collections:DFAR - Artigos publicados em revistas científicas

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