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Title in Portuguese: Polymorphism of IL10, IL4, CTLA4, and DAO genes in cross-reactive nonsteroidal anti-inflammatory drug hypersensitivity
Author: Vasconcelos, Luciana Mabel Ferreira
Rodrigues, Raphael de Oliveira
Albuquerque, Andressa Almeida
Barroso, Gabrielle Dantheias
Sasahara, Greyce Luri
Ferreira, Janaira Fernandes Severo
Francelino, Eudiana Vale
Cardoso, Cynthia Chester
Rabenhorst, Silvia Helena Barem
Almeida, Thereza Lúcia Prata de
Nagao-Dias, Aparecida Tiemi
Keywords: Interleucina-10
Issue Date: 2017
Publisher: Journal of clinical pharmacology
Citation: VASCONCELOS, L. M. F. et al. Polymorphism of IL10, IL4, CTLA4, and DAO genes in cross-reactive nonsteroidal anti-inflammatory drug hypersensitivity. Journal of clinical pharmacology, Stamford, p. 1-7, 2017.
Abstract: Our aim was to evaluate genetic polymorphism of molecules involved in immunoregulatory/allergic processes in patients who presented with cutaneous hypersensitivity caused by chemically unrelated nonsteroidal anti-inflammatory drugs. Polymorphisms at IL10 (–1082 G>A), IL4 (–589 C>T), CTLA4 (+49A>G), and DAO (+8956 C>G) genes were studied in 55 cases and 97 controls by the polymerase chain reaction-restriction fragment length polymorphism technique.With regard to the polymorphism at IL10 –1082, higher frequencies of the AG genotype (57% vs 39%) and G allele carriers (70% vs 48%) were found among the patients, indicating a risk effect (odds ratio [OR] = 2.56 and P = .01 for AG genotype and OR = 2.52; P = .01 for AG/GG). For the CTLA4 +49 A/G single-nucleotide polymorphism (SNP),AG genotype (31.0%) (P = .02) and G carrier (54.0%) (P = .05) frequencies were found to be significantly lower in the patient group compared with the control group (51.0% and 69.0%, respectively). The SNP DAO +8956 C>G was associated with a strong protective effect, with OR values of 0.83 for CG and 0.11 for GG genotype (P = .04 for the codominant model), suggesting an allele dose effect. The combination of IL10 and DAO SNPs in a multivariate model did not alter the OR values, suggesting independent effects for both SNPs. The results are striking. In conclusion, these results suggest that polymorphisms in regulatory targets of the immune response and in DAO gene could modulate an individual’s susceptibility to nonsteroidal anti-inflammatory drug hypersensitivity reactions. Further studies will be necessary to complement our results.
metadata.dc.type: Artigo de Periódico
ISSN: 0091-2700
Appears in Collections:DFAR - Artigos publicados em revistas científicas

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