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Title in Portuguese: Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L -lysine
Author: Santos, Alessandra Marques dos
Coelho, Joao Paulo Ferreira
Juanes, Camila de Carvalho
Azevedo, Rafael Barbosa de
Diniz, Clara Araujo
Jamacaru, Francisco Vagnaldo Fechine
Dornelas, Conceição Aparecida
Keywords: Carcinogênese
Issue Date: Apr-2017
Publisher: Acta Cirurgica Brasileira
Citation: SANTOS, A. M. dos et al. Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L -lysine. Acta Cirurgica Brasileira, São Paulo, v. 32, n. 3, p. 297-306, apr. 2017.
Abstract: Purpose: To evaluated the effects of L-lysine on the intestinal and urothelial epithelia in cystoplasty in rats. Methods: Twenty-eight 9-week-old rats were assigned to 4 groups: Group A (n=8) cystoplasty followed by administration of L-lysine (150 mg/kg body weight by gavage) for 30 weeks; Group B (n=8) cystoplasty + water for 30 weeks; Group C (n=6) L-lysine for 30 weeks; Group D (n=6) water for 30 weeks. Results: On histopathology with hematoxylin and eosin, mild to moderate hyperplasia transitional was observed in at the site of anastomosis in all animals submitted to cystoplasty (Groups A and B), but "transitional metaplasia" of the intestinal glandular epithelium was more accentuated in Group A (p=0.045). No inflammatory cells, dysplasia or abnormalities were observed. Staining with Alcian blue revealed a substantial reduction of goblet cells and mucins in the colon segment (Groups A and B). Conclusion: The administration of L-lysine to rats accelerated the development of transitional metaplasia in the epithelium of the colon segment in cystoplasty.
metadata.dc.type: Artigo de Periódico
ISSN: 1678-2674 On line
Appears in Collections:DCIR - Artigos publicados em revista científica

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