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Title in Portuguese: Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting sex- and age-related behavioral and immune/neurotrophic alterations in mice : relevance to autism spectrum disorders
Author: Custódio, Charllyany Sabino
Mello, Bruna Stefânia Ferreira
Chaves Filho, Adriano José Maia
Lima, Camila Nayane de Carvalho
Cordeiro, Rafaela Carneiro
Miyajima, Fábio Miyajima
Vasconcelos, Silvânia Maria Mendes
Barichello, Tatiana
Quevedo, João
Oliveira, Antônio Carlos de
Lucena, David Freitas de
Réus, Gislaine Z.
Macedo, Danielle S.
Keywords: Caracteres Sexuais
Sex Differences
Issue Date: May-2017
Publisher: Molecular Neurobiology
Citation: CUSTÓDIO, C. S. et al. Neonatal immune challenge with lipopolysaccharide triggers long-lasting sex- and age-related behavioral and immune/neurotrophic alterations in mice : relevance to autism spectrum disorders. Molecular Neurobiology, p. 1-14, 2017.
Abstract: Early-life challenges, particularly infections and stress, are related to neuropsychiatric disorders such as autism and schizophrenia. Here, we conducted a wide range of behavioral tests in periadolescent (postnatal day (PN) 35) and adult (PN70) Swiss mice neonatally challenged with LPS on PN5 and -7, to unveil behavioral alterations triggered by LPS exposure. Immune and neurotrophic (brain-derived neurotrophic factor—BDNF) alterations were determined in the prefrontal cortex (PFC), hippocampus (HC), and hypothalamus (HT). Since the incidence and clinical manifestations of neurodevelopmental disorders present significant sex-related differences, we sought to distinctly evaluate male and female mice. While on PN35, LPS-challenged male mice presented depressive, anxiety-like, repetitive behavior, and working memory deficits; on PN70, only depressive- and anxiety-like behaviors were observed. Conversely, females presented
metadata.dc.type: Artigo de Periódico
ISSN: 0893-7648 (print version)
1559-1182 (electronic version)
Appears in Collections:DPML - Artigos publicados em revista científica

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