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http://repositorio.ufc.br/handle/riufc/23633
Tipo: | Artigo de Periódico |
Título: | In vitro evaluation of anti-Leishmania and anti-Trypanosoma cruzi activity of viperidae venoms |
Autor(es): | Rosas, Nathalia Santiago Cezar Spencer, Patrick Jack Carvalho, Camila Aparecida Silveira, João Alison de Moraes Vasconcelos-Filho, Francisco Sérgio Lopes Monteiro, Helena Serra Azul Bevilaqua, Claudia Maria Leal Andrade Junior, Heitor Franco de Evangelista, Janaina Serra Azul Monteiro |
Palavras-chave: | Doença de Chagas;Chagas Disease;Trypanosoma cruzi |
Data do documento: | Ago-2016 |
Instituição/Editor/Publicador: | Asian Journal of Science and Technology |
Citação: | ROSAS, N. S. C. et al. In vitro evaluation of anti -leishmania and anti -trypanosoma cruzi activity of viperidae venoms. Asian Journal of Science and Technology, v. 7, n. 8, p.3362-3366, aug. 2016. |
Abstract: | The chemotherapy available for the treatment of Leishmaniosis and Chagas is restricted to a few medicines. Moreover, snake venoms have been studied because they have active substances with therapeutic potential. Thus, the aim of this study was to evaluate the in vitro effects of total venom of Crotalusdurissuscascavella , Crotalusdurissusterrificus and Bothropsjararaca in Leishmania chagasi and Trypanosoma cruzi .RAW264.7 and LLC - MK2 cells, L. chagasi promastigote and trypomastigotes of T. cruzi. In L.chagasi amastigotes of T. cruzi was carried out in situ ELISA test and MTT test. The toxins concentration of 500 μg/mL showed 100% mortality on the cells studied. Since of the 250 μg/mL concentration had obtained less than 50% cytotoxicity. These results presente d high toxicity in trypomastigotes and amastigotes of T.cruzi . In promastigotes, the venom of C. d. terrificus caused 71.1% mortality at a concentration of 250 μg/mL and the IC50 of 63.5 to 155.0 mg/mL. In L. chagasi amastigotes, 250 μg/mL the Bothrops jar araca venom caused 96% mortality and a lower IC50 value with the range of 55.6 to 90.9 μg/mL. Therefore, the venoms of C. d. terrificus and B. jararaca in the concentrations tested had anti - Leishmaniosis and anti - Chagas disease activity |
URI: | http://www.repositorio.ufc.br/handle/riufc/23633 |
ISSN: | 0976 - 3376 |
Aparece nas coleções: | PPGF - Artigos publicados em revistas científica |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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2016_art_nscrosas.pdf | 319,51 kB | Adobe PDF | Visualizar/Abrir |
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